HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: SAFB1 (Q15424)
Scaffold attachment factor B1 (SAF-B) (SAF-B1) (HSP27 estrogen response element-TATA box-binding protein) (HSP27 ERE-TATA-binding protein)
Gene: SAFB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	1.00	0.890

Property	Details
Experiments	26496610, 10212141, 34079125, 22446626
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 915
+	Hs
		453353 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		SAFB2_HUMAN (1-906): 1.05e-88: 305: 68.34
+	Hs
		453652 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		SLTM_HUMAN (29-828): 1.63e-50: 195: 30.24
+	Hs
		201699 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		MSI2H_HUMAN (297-559): 1.06e-53: 191: 14.34
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (258-499): 1.89e-40: 161: 15.29
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (258-499): 7.93e-38: 153: 14.51
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (258-499): 1.89e-40: 161: 15.29
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (258-499): 7.93e-38: 153: 14.51
+	Mm
		1142607 MSI1H_MOUSE (2-340): 8.71e-59: 196: 27.87		MSI1H_MOUSE (300-495): 3.73e-37: 145: 18.18
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (258-499): 7.93e-38: 153: 14.51
+	Hs
		516424 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP1_HUMAN (258-499): 7.93e-38: 153: 14.51
+	Hs
		198832 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		RFOX2_HUMAN (301-501): 9.17e-31: 127: 21.80
+	Hs
		198809 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RFOX2_HUMAN (301-501): 9.17e-31: 127: 21.80
+	Hs
		62520 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		RFOX3_HUMAN (307-501): 3.08e-30: 124: 20.00
+	Hs
		453526 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP5_HUMAN (410-755): 3.8e-25: 110: 11.38
+	Hs
		852134 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP5_HUMAN (410-755): 3.8e-25: 110: 11.38
+	Hs
		516689 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		PABP1_HUMAN (258-499): 7.93e-38: 153: 14.51
+	Hs
		516663 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (258-499): 7.93e-38: 153: 14.51
+	Hs
		201642 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		MSI1H_HUMAN (260-408): 3.28e-13: 74.1: 8.00
+	Hs
		198968 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		RFOX2_HUMAN (301-501): 9.17e-31: 127: 21.80
+	Hs
		198880 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		RFOX2_HUMAN (301-501): 9.17e-31: 127: 21.80