HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 33596420
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010634 - positive regulation of epithelial cell migration GO:0031267 - small GTPase binding GO:0098978 - glutamatergic synapse
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 1865
+	Hs
		459674 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		DOCK4_HUMAN (4-1855): 0: 1743: 36.35
+	Hs
		459721 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		DOCK7_HUMAN (736-996): 5.84e-50: 198: 10.47
+	Hs
		459684 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		DOCK8_HUMAN (707-1086): 2.61e-39: 163: 9.09
+	Hs
		459419 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		TAU_HUMAN (1502-1858): 2.38e-26: 119: 12.30
+	Hs
		529206 PROF2_HUMAN (1-140): 1.14e-74: 220: 61.43		TAU_HUMAN (1502-1858): 2.38e-26: 119: 12.30
+	Mm
		986967 PROF1_MOUSE (1-140): 5.4e-77: 226: 95.71		PCLO_MOUSE (1580-1840): 8.07e-09: 63.2: 11.91
+	Mm
		1440872 PROF2_MOUSE (1-140): 9.87e-75: 220: 61.43		PCLO_MOUSE (1580-1840): 8.07e-09: 63.2: 11.91