Protein: PROF2
Profilin-2 (Profilin II)

Gene: PROF2, PFN2
Organism: Homo sapiens
Interactions: 122
UniProt ID: P35080

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0003785 - actin monomer binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm
GO:0005856 - cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

762435

ACTB
Actin, cytoplasmic 1

3

16

High-throughput

0.871

High

762442

ACTG
Actin, cytoplasmic 2

2

16

High-throughput

0.817

High

762440

ACTA
Actin, aortic smooth muscle

2

16

High-throughput

0.811

High

762461

ACTBL
Beta-actin-like protein 2

2

16

High-throughput

0.811

High

762429

VASP
Vasodilator-stimulated phosphoprotein

5

10

Small-scale

0.724

High

762443

ACTC
Actin, alpha cardiac muscle 1

1

14

High-throughput

0.665

High

762423

HD
Huntingtin

2

2

High-throughput

0.631

High

252419

DIAP1
Protein diaphanous homolog 1

2

10

High-throughput

0.628

High

762460

INF2
Inverted formin-2

2

11

High-throughput

0.628

High

762467

ENAH
Protein enabled homolog

2

10

High-throughput

0.628

High

762473

PALLD
Palladin

2

3

High-throughput

0.628

High

762479

NAA80
N-alpha-acetyltransferase 80

2

1

High-throughput

0.628

High

762505

EVL
Ena/VASP-like protein

2

10

Small-scale

0.619

High

762459

SMN
Survival motor neuron protein

2

0

Small-scale

0.585

High

762422

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

762481

OTUB1
Ubiquitin thioesterase OTUB1

2

1

High-throughput

0.571

High

337566

FMNL1
Formin-like protein 1

1

12

Small-scale

0.561

High

762453

BIRC2
Baculoviral IAP repeat-containing protein 2

1

2

Small-scale

0.552

High

226717

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

1

High-throughput

0.541

High

762425

RPGP1
Rap1 GTPase-activating protein 1

1

1

High-throughput

0.541

High

762444

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.541

High

762485

SEPT5
Septin-5

1

1

High-throughput

0.541

High

529206

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.536

High

762426

KC1D
Casein kinase I isoform delta

1

2

High-throughput

0.536

High

762454

GOGB1
Golgin subfamily B member 1

1

6

High-throughput

0.532

High

762451

SNTA1
Alpha-1-syntrophin

1

2

Small-scale

0.527

High

762424

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.518

High

762430

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

762447

RED
Protein Red

1

0

High-throughput

0.518

High

762450

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

0

High-throughput

0.518

High

762480

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.518

High

762498

RN146
E3 ubiquitin-protein ligase RNF146

1

0

High-throughput

0.518

High

762515

NS1BP
Influenza virus NS1A-binding protein

1

0

High-throughput

0.518

High

159953

IDLC
Axonemal dynein light intermediate polypeptide 1

1

0

High-throughput

0.513

High

716368

BLVRB
Flavin reductase

1

0

High-throughput

0.513

High

762448

SBP1
Methanethiol oxidase

1

0

High-throughput

0.513

High

762472

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.513

High

762506

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

762446

ERCC6
DNA excision repair protein ERCC-6

1

1

High-throughput

0.501

High

762420

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.494

High

176033

KDM6B
Lysine-specific demethylase 6B

1

4

High-throughput

0.489

High

484405

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

762465

DSG4
Desmoglein-4

1

1

High-throughput

0.489

High

762514

FHOD1
FH1/FH2 domain-containing protein 1

1

11

Small-scale

0.481

High

240894

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

315198

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

323200

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.479

High

442248

GELS
Gelsolin

1

2

High-throughput

0.479

High

536611

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

538890

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

580894

RAC2
Ras-related C3 botulinum toxin substrate 2

1

4

High-throughput

0.479

High

611008

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

762427

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

762441

RHOB
Rho-related GTP-binding protein RhoB

1

6

High-throughput

0.479

High

762452

ROCK1
Rho-associated protein kinase 1

1

1

Small-scale

0.479

High

762458

CCDC6
Coiled-coil domain-containing protein 6

1

3

High-throughput

0.479

High

762464

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

762466

SESD1
SEC14 domain and spectrin repeat-containing protein 1

1

3

High-throughput

0.479

High

762468

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

1

Small-scale

0.479

High

762471

RIN3
Ras and Rab interactor 3

1

5

High-throughput

0.479

High

762476

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

762477

WASF1
Actin-binding protein WASF1

1

7

Small-scale

0.479

High

762487

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

762488

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

762489

TRI31
E3 ubiquitin-protein ligase TRIM31

1

4

High-throughput

0.479

High

762494

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

762499

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

762502

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

762504

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

High-throughput

0.479

High

762507

BAG5
BAG family molecular chaperone regulator 5

1

1

High-throughput

0.479

High

762508

MYO6
Unconventional myosin-VI

1

3

High-throughput

0.479

High

762513

TRAF6
TNF receptor-associated factor 6

1

6

High-throughput

0.479

High

293286

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

379910

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

762421

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.458

High

762432

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

762433

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.458

High

762439

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

762449

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.458

High

762455

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

762463

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

762474

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.458

High

762483

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

762495

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

762496

GEMI7
Gem-associated protein 7

1

0

High-throughput

0.458

High

762500

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.458

High

762503

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

762509

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.458

High

762511

STRAP
Serine-threonine kinase receptor-associated protein

1

0

High-throughput

0.458

High

762512

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

762470

MUC7
Mucin-7

1

4

Small-scale

0.457

High

705255

GRN
Progranulin

1

1

High-throughput

0.445

High

762431

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

762434

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

High-throughput

0.445

High

762462

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

762490

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

642660

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

762436

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

762457

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

762475

ASB12
Ankyrin repeat and SOCS box protein 12

1

7

High-throughput

0.437

High

762478

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

762510

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

762493

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.407

High

328358

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

1

0

High-throughput

0.282

High

762445

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.282

High

762482

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.282

High

762486

ANKMT
Adenine nucleotide translocase lysine N-methyltransferase

1

0

High-throughput

0.282

High

762491

WDR33
pre-mRNA 3' end processing protein WDR33

1

0

High-throughput

0.282

High

762492

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.282

High

326667

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

105447

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

167061

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.249

Low

417972

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

472478

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

762437

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.249

Low

762438

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.249

Low

762456

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.249

Low

762469

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.249

Low

762484

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.249

Low

762497

NGB
Neuroglobin

1

0

High-throughput

0.249

Low

762501

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.249

Low

762428

FLT3L
Fms-related tyrosine kinase 3 ligand

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025