Protein: DOCK4
Dedicator of cytokinesis protein 4

Gene: DOCK4
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q8N1I0

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

987768

GRB2
Growth factor receptor-bound protein 2

7

20

High-throughput

0.961

High

1323639

ELMO1
Engulfment and cell motility protein 1

4

20

Small-scale

0.897

High

1323644

ELMO2
Engulfment and cell motility protein 2

3

20

High-throughput

0.849

High

838137

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

1

High-throughput

0.811

High

1323642

ELMO3
Engulfment and cell motility protein 3

2

20

High-throughput

0.811

High

1323640

ARHG1
Rho guanine nucleotide exchange factor 1

2

4

High-throughput

0.754

High

1316229

DOCK3
Dedicator of cytokinesis protein 3

1

12

High-throughput

0.691

High

1323647

ERMAP
Erythroid membrane-associated protein

2

3

High-throughput

0.628

High

1022421

IDD
Integral membrane protein DGCR2/IDD

2

1

High-throughput

0.618

High

988519

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1154126

ITSN1
Intersectin-1

1

4

High-throughput

0.618

High

1323646

ARHGH
Rho guanine nucleotide exchange factor 17

1

4

High-throughput

0.618

High

882529

ARRB1
Beta-arrestin-1

2

0

High-throughput

0.602

High

363560

EGFR
Epidermal growth factor receptor

2

16

Small-scale

0.584

High

1323648

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

3

High-throughput

0.575

High

531107

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

High-throughput

0.571

High

1186453

RHGBB
Inactive Rho GTPase-activating protein 11B

2

8

High-throughput

0.571

High

516692

VSIG8
V-set and immunoglobulin domain-containing protein 8

2

5

High-throughput

0.552

High

388245

GLPA
Glycophorin-A

1

2

High-throughput

0.536

High

1323641

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

1

1

High-throughput

0.536

High

1323658

NPTN
Neuroplastin

1

2

High-throughput

0.536

High

532764

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

730044

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.515

High

914296

EFNA4
Ephrin-A4

1

0

High-throughput

0.513

High

1310219

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1323652

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

161058

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

5

Small-scale

0.501

High

576461

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.493

High

1323657

RN115
E3 ubiquitin-protein ligase RNF115

1

1

Small-scale

0.481

High

869503

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

Small-scale

0.480

High

141568

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

412248

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

437270

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

459674

PROF1
Profilin-1

1

5

High-throughput

0.479

High

474816

VIME
Vimentin

1

3

High-throughput

0.479

High

762025

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.479

High

799291

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

807495

IF4A3
Eukaryotic initiation factor 4A-III

1

3

High-throughput

0.479

High

878511

PAXI
Paxillin

1

5

High-throughput

0.479

High

908142

KS6A3
Ribosomal protein S6 kinase alpha-3

1

6

High-throughput

0.479

High

954192

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

966600

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

970766

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

1049545

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1146436

KS6A2
Ribosomal protein S6 kinase alpha-2

1

6

High-throughput

0.479

High

1148361

KS6A1
Ribosomal protein S6 kinase alpha-1

1

6

High-throughput

0.479

High

1252123

SYNE3
Nesprin-3

1

5

High-throughput

0.479

High

1253724

RHG36
Rho GTPase-activating protein 36

1

6

High-throughput

0.479

High

1254608

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.479

High

1323638

BICD2
Protein bicaudal D homolog 2

1

4

High-throughput

0.479

High

1323643

BICD1
Protein bicaudal D homolog 1

1

4

High-throughput

0.479

High

1323650

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

1323651

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.479

High

1323655

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1323656

MARE3
Microtubule-associated protein RP/EB family member 3

1

3

High-throughput

0.479

High

176514

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

317888

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

350070

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

447213

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

961061

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

983310

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

1323645

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.458

High

1323654

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

Small-scale

0.458

High

166343

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.445

High

1203192

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.445

High

106253

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

1323653

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

1

High-throughput

0.437

High

1258502

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

1

High-throughput

0.407

High

1241905

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1242773

RL22L
Ribosomal protein eL22-like

1

0

High-throughput

0.249

Low

1323649

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025