Protein: DOCK8
Dedicator of cytokinesis protein 8

Gene: DOCK8
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q8NF50

Gene Ontology (top 5):
GO:0001771 - immunological synapse formation
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1338511

DOCK7
Dedicator of cytokinesis protein 7

7

11

High-throughput

0.965

High

1338508

DOCK6
Dedicator of cytokinesis protein 6

3

11

High-throughput

0.871

High

955389

CDC42
Cell division control protein 42 homolog

2

20

Small-scale

0.757

High

1338529

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

8

12

High-throughput

0.751

High

1338510

LRCH3
DISP complex protein LRCH3

7

12

High-throughput

0.749

High

1338500

DOCK8
Dedicator of cytokinesis protein 8

1

11

High-throughput

0.698

High

281533

LRCH4
Leucine-rich repeat and calponin homology domain-containing protein 4

4

12

High-throughput

0.696

High

179538

ARPC3
Actin-related protein 2/3 complex subunit 3

3

1

High-throughput

0.667

High

1218299

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

5

12

High-throughput

0.657

High

894036

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.633

High

1338503

APBP2
Amyloid protein-binding protein 2

2

1

High-throughput

0.628

High

1338523

CPNE7
Copine-7

2

1

High-throughput

0.628

High

988538

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.621

High

1338521

FXL12
F-box/LRR-repeat protein 12

2

0

High-throughput

0.618

High

374075

RASN
GTPase NRas

1

13

High-throughput

0.618

High

374785

RASH
GTPase HRas

1

10

High-throughput

0.618

High

375744

RASK
GTPase KRas

1

14

High-throughput

0.618

High

1338518

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1273117

MOB1B
MOB kinase activator 1B

2

11

High-throughput

0.584

High

1338517

MOB1A
MOB kinase activator 1A

2

11

High-throughput

0.584

High

269303

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

1230152

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.573

High

358751

LDHA
L-lactate dehydrogenase A chain

2

3

High-throughput

0.571

High

424227

S10A8
Protein S100-A8

2

4

High-throughput

0.571

High

445031

S10A9
Protein S100-A9

2

5

High-throughput

0.571

High

451032

LDHB
L-lactate dehydrogenase B chain

2

3

High-throughput

0.571

High

456802

ANXA2
Annexin A2

2

4

High-throughput

0.571

High

459684

PROF1
Profilin-1

2

3

High-throughput

0.571

High

466046

ANXA6
Annexin A6

2

4

High-throughput

0.571

High

476173

ANXA5
Annexin A5

2

4

High-throughput

0.571

High

552841

TPR
Nucleoprotein TPR

2

4

High-throughput

0.571

High

553242

KCRB
Creatine kinase B-type

2

1

High-throughput

0.571

High

647604

UBA1
Ubiquitin-like modifier-activating enzyme 1

2

1

High-throughput

0.571

High

669947

MCM3
DNA replication licensing factor MCM3

2

1

High-throughput

0.571

High

724605

S10A7
Protein S100-A7

2

5

High-throughput

0.571

High

760971

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

1

High-throughput

0.571

High

774505

BASI
Basigin

2

2

High-throughput

0.571

High

790927

TAGL2
Transgelin-2

2

6

High-throughput

0.571

High

813479

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

2

1

High-throughput

0.571

High

868741

LEG7
Galectin-7

2

1

High-throughput

0.571

High

987125

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

1

High-throughput

0.571

High

1052067

CALD1
Caldesmon

2

4

High-throughput

0.571

High

1062265

TGM3
Protein-glutamine gamma-glutamyltransferase E

2

2

High-throughput

0.571

High

1338514

SRSF8
Serine/arginine-rich splicing factor 8

2

2

High-throughput

0.571

High

1338526

MAGD2
Melanoma-associated antigen D2

2

2

High-throughput

0.571

High

221870

CHM2A
Charged multivesicular body protein 2a

1

0

High-throughput

0.549

High

1118929

BYST
Bystin

1

0

High-throughput

0.549

High

1135983

RTP5
Receptor-transporting protein 5

1

0

High-throughput

0.549

High

1185290

F161A
Protein FAM161A

1

0

High-throughput

0.549

High

1338519

EXOS5
Exosome complex component RRP46

1

0

High-throughput

0.549

High

1338520

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

High-throughput

0.549

High

1338531

CHSP1
Calcium-regulated heat-stable protein 1

1

0

High-throughput

0.549

High

134096

IPO5
Importin-5

2

0

High-throughput

0.547

High

365428

PGK1
Phosphoglycerate kinase 1

2

0

High-throughput

0.547

High

417604

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.547

High

418284

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.547

High

431194

LA
Lupus La protein

2

0

High-throughput

0.547

High

643521

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

2

0

High-throughput

0.547

High

646893

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

2

0

High-throughput

0.547

High

648205

NDKB
Nucleoside diphosphate kinase B

2

0

High-throughput

0.547

High

716586

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

2

0

High-throughput

0.547

High

869922

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

2

0

High-throughput

0.547

High

949186

TPIS
Triosephosphate isomerase

2

0

High-throughput

0.547

High

962985

CH10
10 kDa heat shock protein, mitochondrial

2

0

High-throughput

0.547

High

1099168

SRSF5
Serine/arginine-rich splicing factor 5

2

0

High-throughput

0.547

High

1156393

SEPT7
Septin-7

2

0

High-throughput

0.547

High

1338501

TM263
Transmembrane protein 263

2

0

High-throughput

0.547

High

1338505

LRC59
Leucine-rich repeat-containing protein 59

2

0

High-throughput

0.547

High

1338527

PA2G4
Proliferation-associated protein 2G4

2

0

High-throughput

0.547

High

347818

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.536

High

1307692

CRLF3
Cytokine receptor-like factor 3

1

2

High-throughput

0.536

High

1338504

FAN
Protein FAN

1

2

High-throughput

0.536

High

1338512

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

380713

HBAZ
Hemoglobin subunit zeta

1

1

High-throughput

0.523

High

1338522

ZN581
Zinc finger protein 581

1

1

High-throughput

0.523

High

571477

GLU2B
Glucosidase 2 subunit beta

2

1

High-throughput

0.521

High

666330

THIL
Acetyl-CoA acetyltransferase, mitochondrial

2

1

High-throughput

0.521

High

717549

PDIA3
Protein disulfide-isomerase A3

2

2

High-throughput

0.521

High

1042034

LMNB2
Lamin-B2

2

2

High-throughput

0.521

High

257060

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

0

High-throughput

0.513

High

1338513

MYD88
Myeloid differentiation primary response protein MyD88

1

0

Small-scale

0.513

High

1153839

SMAD2
Mothers against decapentaplegic homolog 2

1

4

High-throughput

0.508

High

883118

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.493

High

1338507

RM38
Large ribosomal subunit protein mL38

1

1

High-throughput

0.481

High

159241

ABLM1
Actin-binding LIM protein 1

1

1

High-throughput

0.479

High

170242

AURKA
Aurora kinase A

1

5

High-throughput

0.479

High

173098

XPO1
Exportin-1

1

4

High-throughput

0.479

High

463660

LYN
Tyrosine-protein kinase Lyn

1

7

Small-scale

0.479

High

557391

SRC
Proto-oncogene tyrosine-protein kinase Src

1

7

Small-scale

0.479

High

623453

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

731475

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

1036768

DSG1
Desmoglein-1

1

1

High-throughput

0.479

High

1115306

CUL4B
Cullin-4B

1

5

High-throughput

0.479

High

1338506

OPTN
Optineurin

1

5

High-throughput

0.479

High

1338524

XPO7
Exportin-7

1

4

High-throughput

0.479

High

1338525

MYO6
Unconventional myosin-VI

1

3

High-throughput

0.479

High

69852

A8K900
Mitochondrial GTPase 1

1

1

High-throughput

0.470

High

73642

B2R894
Large ribosomal subunit protein mL38

1

1

High-throughput

0.470

High

108037

G3V1X1
Proline/serine-rich coiled-coil 2, isoform CRA_a

1

1

High-throughput

0.470

High

1232473

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

483158

CLCA
Clathrin light chain A

1

0

High-throughput

0.458

High

656194

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

High-throughput

0.458

High

973983

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

1202207

DCAF6
DDB1- and CUL4-associated factor 6

1

0

High-throughput

0.458

High

1338502

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

1338528

RUVB1
RuvB-like 1

1

0

High-throughput

0.458

High

1125287

FAK2
Protein-tyrosine kinase 2-beta

1

9

Small-scale

0.445

High

1243510

CSAG1
Chondrosarcoma-associated gene 1 protein

1

3

High-throughput

0.445

High

244740

ZC3H1
Zinc finger C3H1 domain-containing protein

1

1

High-throughput

0.439

High

1120868

DGCR6
Protein DGCR6

1

1

High-throughput

0.439

High

1338516

MTG1
Mitochondrial ribosome-associated GTPase 1

1

1

High-throughput

0.439

High

471142

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.437

High

143458

E2F3
Transcription factor E2F3

1

0

Small-scale

0.426

High

1338535

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

1338534

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

3

High-throughput

0.407

High

887036

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

1338532

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

1289920

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

1338509

MED30
Mediator of RNA polymerase II transcription subunit 30

1

0

High-throughput

0.299

High

279836

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.298

High

484597

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

0

High-throughput

0.298

High

634137

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

2

0

High-throughput

0.298

High

932914

P5CS
Delta-1-pyrroline-5-carboxylate synthase

2

0

High-throughput

0.298

High

1213288

RM02
Large ribosomal subunit protein uL2m

2

0

High-throughput

0.298

High

1338533

LC7L2
Putative RNA-binding protein Luc7-like 2

2

0

High-throughput

0.298

High

1338515

PIMRE
Protein PIMREG

1

0

High-throughput

0.282

High

1121640

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.279

Low

472905

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.249

Low

521818

H14
Histone H1.4

1

0

High-throughput

0.249

Low

590923

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

1149135

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.249

Low

1338530

RT28
Small ribosomal subunit protein bS1m

1

0

High-throughput

0.249

Low

1253195

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025