HitPredict

Interactor 1: PROF1 (P07737)
Profilin-1 (Epididymis tissue protein Li 184a) (Profilin I)
Gene: PFN1

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	34079125, 9473484
Identification Methods	proximity labelling technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005925 - focal adhesion
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 591
+	Hs
		762467 PROF2_HUMAN (1-140): 1.14e-74: 220: 61.43		ENAH_HUMAN (1-591): 2.14e-77: 258: 100.00
+	Hs
		459606 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		ITSN1_HUMAN (124-263): 2.98e-29: 125: 37.59
+	Mm
		1000464 PROF2_MOUSE (1-140): 9.87e-75: 220: 61.43		VASP_MOUSE (380-590): 1.29e-29: 122: 33.18
+	Hs
		459791 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		EVL_HUMAN (1-374): 7.45e-27: 115: 32.71
+	Hs
		459701 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		TITIN_HUMAN (81-495): 1.62e-25: 114: 11.06
+	Hs
		762505 PROF2_HUMAN (1-140): 1.14e-74: 220: 61.43		EVL_HUMAN (1-374): 7.45e-27: 115: 32.71
+	Hs
		459505 PROF1_HUMAN (1-140): 1.1e-77: 227: 100.00		VASP_HUMAN (263-590): 7.71e-20: 93.6: 29.18
+	Mm
		986949 PROF1_MOUSE (1-140): 5.4e-77: 226: 95.71		ENAH_MOUSE (242-591): 1.86e-17: 88.4: 74.57
+	Hs
		762429 PROF2_HUMAN (1-140): 1.14e-74: 220: 61.43		VASP_HUMAN (263-590): 7.71e-20: 93.6: 29.18
+	Mm
		1041729 PROF2_MOUSE (1-140): 9.87e-75: 220: 61.43		ENAH_MOUSE (242-591): 1.86e-17: 88.4: 74.57