HitPredict

Interactor 1: PROF2 (P35080)
Profilin-2 (Profilin II)
Gene: PFN2

Interactor 2: VASP (P50552)
Vasodilator-stimulated phosphoprotein (VASP)
Gene: VASP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.724

Property	Details
Experiments	10882740, 28514442, 7737110, 33961781, unassigned3799
Identification Methods	two hybrid, affinity chromatography technology, pull down, biochemical, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0030838 - positive regulation of actin filament polymerization GO:0070062 - extracellular exosome GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 380
+	Mm
		1000464 PROF2_MOUSE (1-140): 3.32e-76: 224: 99.29		VASP_MOUSE (1-380): 3.1e-96: 293: 87.63
+	Hs
		459505 PROF1_HUMAN (1-140): 4.27e-74: 219: 61.43		VASP_HUMAN (1-380): 1.44e-91: 281: 100.00
+	Hs
		762505 PROF2_HUMAN (1-140): 2.85e-76: 224: 100.00		EVL_HUMAN (1-375): 2.07e-60: 202: 43.68
+	Hs
		459791 PROF1_HUMAN (1-140): 4.27e-74: 219: 61.43		EVL_HUMAN (1-375): 2.07e-60: 202: 43.68
+	Hs
		762467 PROF2_HUMAN (1-140): 2.85e-76: 224: 100.00		ENAH_HUMAN (109-379): 3.93e-23: 102: 30.06
+	Hs
		459677 PROF1_HUMAN (1-140): 4.27e-74: 219: 61.43		ENAH_HUMAN (109-379): 3.93e-23: 102: 30.06
+	Mm
		1041729 PROF2_MOUSE (1-140): 3.32e-76: 224: 99.29		ENAH_MOUSE (109-379): 3.13e-16: 82.4: 28.17
+	Mm
		986949 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		ENAH_MOUSE (109-379): 3.13e-16: 82.4: 28.17
+	Mm
		1440872 PROF2_MOUSE (1-140): 3.32e-76: 224: 99.29		PCLO_MOUSE (95-300): 3.84e-09: 60.8: 13.59
+	Mm
		986967 PROF1_MOUSE (1-140): 1.25e-73: 217: 62.86		PCLO_MOUSE (95-300): 3.84e-09: 60.8: 13.59