HitPredict

Interactor 1: HS90A (P07900)
Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Heat shock protein family C member 1) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
Gene: HSP90AA1

Interactor 2: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.992

Property	Details
Experiments	24462205, 26496610, 19996313, 26804907, 11413142, 27353360, 35271311, 35760815, 34349018, 37071682, 39358380, 26414014, 20159553, 21170051, 20704274, 22315411, 22729780, 19875381, 21360678, 11877417 and 10 others more... 10642522, 18285346, 22504172, 28514442, 10786835, 9452498, 33961781, 33239621, 21235734, 25036637
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	HSP90~STI1-HOP_DP, HSP90~TPR_12, HSP90~TPR_2, HSP90~TPR_8
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 732 Hs			1 543
+	Hs
		117617 K9JA46_HUMAN (1-732): 0: 1085: 100.00		STIP1_HUMAN (1-543): 2.06e-97: 307: 100.00
+	Hs
		468113 HS90B_HUMAN (19-732): 0: 1057: 86.13		STIP1_HUMAN (1-543): 2.06e-97: 307: 100.00
+	Dm
		391918 HSP83_DROME (15-732): 0: 1031: 78.41		Q9VPN5_DROME (1-542): 1.57e-75: 249: 47.42
+	At
		938316 HS902_ARATH (15-732): 0: 980: 68.24		HSOP2_ARATH (3-543): 2.27e-93: 298: 41.51
+	Hs
		461857 HS90A_HUMAN (1-732): 0: 1085: 100.00		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		461515 HS90A_HUMAN (1-732): 0: 1085: 100.00		TOM34_HUMAN (1-119): 8.16e-23: 100: 26.05
+	Hs
		461939 HS90A_HUMAN (1-732): 0: 1085: 100.00		RPAP3_HUMAN (2-129): 4.51e-20: 96.2: 28.91
+	Hs
		185361 HS90A_HUMAN (1-732): 0: 1085: 100.00		OGT1_HUMAN (5-241): 5.34e-17: 86.9: 12.24
+	Hs
		468729 HS90B_HUMAN (19-732): 0: 1057: 86.13		DNJC7_HUMAN (209-487): 2.86e-26: 114: 18.28
+	Hs
		317975 HS90A_HUMAN (1-732): 0: 1085: 100.00		TOM70_HUMAN (216-543): 8.73e-13: 73.1: 10.73
+	Hs
		468409 HS90B_HUMAN (19-732): 0: 1057: 86.13		TOM34_HUMAN (1-119): 8.16e-23: 100: 26.05
+	Hs
		468809 HS90B_HUMAN (19-732): 0: 1057: 86.13		RPAP3_HUMAN (2-129): 4.51e-20: 96.2: 28.91
+	Hs
		461397 HS90A_HUMAN (1-732): 0: 1085: 100.00		SPAG1_HUMAN (405-527): 2.23e-10: 65.3: 14.63
+	Hs
		461421 HS90A_HUMAN (1-732): 0: 1085: 100.00		IFT88_HUMAN (5-211): 3.51e-10: 65: 14.01
+	Hs
		226672 HS90A_HUMAN (1-732): 0: 1085: 100.00		SGTA_HUMAN (202-327): 4e-09: 60.1: 32.54
+	Hs
		185366 HS90B_HUMAN (19-732): 0: 1057: 86.13		OGT1_HUMAN (5-241): 5.34e-17: 86.9: 12.24
+	Hs
		317976 HS90B_HUMAN (19-732): 0: 1057: 86.13		TOM70_HUMAN (216-543): 8.73e-13: 73.1: 10.73
+	Hs
		226675 HS90B_HUMAN (19-732): 0: 1057: 86.13		SGTA_HUMAN (202-327): 4e-09: 60.1: 32.54
+	Ce
		195281 HSP90_CAEEL (14-732): 0: 959: 74.83		STIP1_CAEEL (356-535): 2.91e-12: 70: 17.11
+	Sp
		836474 HSP90_SCHPO (15-732): 0: 913: 62.08		STI1_SCHPO (2-284): 2.83e-09: 61.9: 9.66