HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RFC1 (P35251)
Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)
Gene: RFC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 1148
+	Hs
		475410 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC1_HUMAN (1-1139): 0: 608: 100.00
+	Hs
		226700 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LONM_HUMAN (275-1000): 2.34e-69: 253: 9.59
+	Hs
		226670 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC4_HUMAN (557-927): 1.06e-72: 248: 19.47
+	Hs
		226739 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Hs
		226671 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26
+	Sc
		477255 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		RFC1_YEAST (268-1148): 1.2e-125: 408: 29.95
+	Hs
		475441 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC5_HUMAN (565-913): 8.86e-65: 225: 19.22
+	Hs
		475409 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC2_HUMAN (561-915): 3.38e-62: 218: 18.26