Protein: TOM70
Mitochondrial import receptor subunit TOM70 (Mitochondrial precursor proteins import receptor) (Translocase of outer membrane 70 kDa subunit) (Translocase of outer mitochondrial membrane protein 70)

Gene: TOM70, TOMM70
Organism: Homo sapiens
Interactions: 130
UniProt ID: O94826

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0002230 - positive regulation of defense response to virus by host
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005742 - mitochondrial outer membrane translocase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317975

HS90A
Heat shock protein HSP 90-alpha

3

20

Small-scale

0.873

High

240337

PRKN
E3 ubiquitin-protein ligase parkin

7

14

Small-scale

0.743

High

185306

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

17

High-throughput

0.647

High

317976

HS90B
Heat shock protein HSP 90-beta

1

20

Small-scale

0.618

High

317978

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.618

High

318008

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

20

High-throughput

0.618

High

317967

TOM40
Mitochondrial import receptor subunit TOM40 homolog

2

5

Small-scale

0.611

High

318037

H2B1H
Histone H2B type 1-H

2

10

High-throughput

0.601

High

318038

TTC28
Tetratricopeptide repeat protein 28

1

17

High-throughput

0.595

High

318043

DDX27
Probable ATP-dependent RNA helicase DDX27

1

8

High-throughput

0.595

High

318054

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

2

16

Small-scale

0.595

High

317964

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

12

High-throughput

0.584

High

317965

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

5

High-throughput

0.584

High

317980

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

2

High-throughput

0.584

High

318013

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

3

Small-scale

0.584

High

318067

MARH5
E3 ubiquitin-protein ligase MARCHF5

2

1

Small-scale

0.584

High

317970

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

318019

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

12

High-throughput

0.571

High

318068

MTCH1
Mitochondrial carrier homolog 1

2

13

High-throughput

0.571

High

318078

MTCH2
Mitochondrial carrier homolog 2

2

19

High-throughput

0.571

High

318010

IRF3
Interferon regulatory factor 3

1

2

Small-scale

0.561

High

318062

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

216594

HTRA2
Serine protease HTRA2, mitochondrial

1

2

High-throughput

0.554

High

318047

IMP1L
Mitochondrial inner membrane protease subunit 1

1

4

High-throughput

0.554

High

318048

IMP2L
Mitochondrial inner membrane protease subunit 2

1

4

High-throughput

0.554

High

317972

HSPB1
Heat shock protein beta-1

1

12

High-throughput

0.541

High

317993

GDIB
Rab GDP dissociation inhibitor beta

1

5

High-throughput

0.536

High

317996

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

4

High-throughput

0.536

High

318024

MAVS
Mitochondrial antiviral-signaling protein

1

12

Small-scale

0.515

High

271204

CPNE3
Copine-3

1

0

High-throughput

0.513

High

318055

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

60277

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.493

High

317990

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.493

High

317984

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.489

High

317987

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

High-throughput

0.489

High

318002

TBA1B
Tubulin alpha-1B chain

1

17

High-throughput

0.489

High

318006

FOXL1
Forkhead box protein L1

1

5

High-throughput

0.489

High

318012

TEBP
Prostaglandin E synthase 3

1

9

High-throughput

0.489

High

318032

RIN3
Ras and Rab interactor 3

1

7

High-throughput

0.489

High

104990

APRIO
Alternative prion protein

1

5

High-throughput

0.479

High

245396

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

4

High-throughput

0.479

High

292045

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

9

High-throughput

0.479

High

317968

EGFR
Epidermal growth factor receptor

1

8

High-throughput

0.479

High

317971

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.479

High

317974

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

317979

ADT3
ADP/ATP translocase 3

1

10

Small-scale

0.479

High

317986

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

2

Small-scale

0.479

High

317999

H2B1D
Histone H2B type 1-D

1

10

High-throughput

0.479

High

318001

H2B1C
Histone H2B type 1-C/E/F/G/I

1

10

High-throughput

0.479

High

318003

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.479

High

318005

KIF23
Kinesin-like protein KIF23

1

6

High-throughput

0.479

High

318009

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

318011

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

318016

H2B2E
Histone H2B type 2-E

1

10

High-throughput

0.479

High

318023

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

5

Small-scale

0.479

High

318025

STING
Stimulator of interferon genes protein

1

3

Small-scale

0.479

High

318030

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

318031

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

318035

AKAP1
A-kinase anchor protein 1, mitochondrial

1

7

High-throughput

0.479

High

318036

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

318042

RN185
E3 ubiquitin-protein ligase RNF185

1

10

Small-scale

0.479

High

318049

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

2

High-throughput

0.479

High

318051

PHB2
Prohibitin-2

1

4

High-throughput

0.479

High

318052

H2B1L
Histone H2B type 1-L

1

10

High-throughput

0.479

High

318056

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

15

Small-scale

0.479

High

318057

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

11

High-throughput

0.479

High

318065

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

318066

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

318070

TBK1
Serine/threonine-protein kinase TBK1

1

15

Small-scale

0.479

High

318072

FBXL4
F-box/LRR-repeat protein 4

1

13

Small-scale

0.479

High

318075

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

318076

TRRAP
Transformation/transcription domain-associated protein

1

8

High-throughput

0.479

High

318077

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.479

High

317995

IRAK1
Interleukin-1 receptor-associated kinase 1

1

4

High-throughput

0.470

High

318026

AHNK2
Protein AHNAK2

1

2

High-throughput

0.470

High

318029

AMPO
Aminopeptidase O

1

3

High-throughput

0.470

High

166831

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

296174

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

318018

MIDN
Midnolin

1

0

High-throughput

0.458

High

318041

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

318044

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

318053

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

318058

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

318063

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

318064

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

317977

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.445

High

317982

GDC
Solute carrier family 25 member 16

1

10

High-throughput

0.445

High

317991

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.445

High

318017

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

2

High-throughput

0.445

High

168793

PLD2
Phospholipase D2

1

6

High-throughput

0.437

High

256721

H2B1K
Histone H2B type 1-K

1

10

High-throughput

0.437

High

317962

EPM2A
Laforin

1

3

High-throughput

0.437

High

317966

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

317973

H2B1J
Histone H2B type 1-J

1

10

High-throughput

0.437

High

317981

RFA2
Replication protein A 32 kDa subunit

1

12

High-throughput

0.437

High

317983

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.437

High

317988

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

11

High-throughput

0.437

High

317989

RFA3
Replication protein A 14 kDa subunit

1

9

High-throughput

0.437

High

317992

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.437

High

317994

CDK7
Cyclin-dependent kinase 7

1

6

High-throughput

0.437

High

317998

KLF3
Krueppel-like factor 3

1

8

High-throughput

0.437

High

318000

WDR5
WD repeat-containing protein 5

1

12

High-throughput

0.437

High

318015

E2F4
Transcription factor E2F4

1

2

High-throughput

0.437

High

318021

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

318022

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.437

High

318028

FBXL6
F-box/LRR-repeat protein 6

1

13

High-throughput

0.437

High

318033

ASB11
Ankyrin repeat and SOCS box protein 11

1

14

High-throughput

0.437

High

318040

OPTN
Optineurin

1

11

High-throughput

0.437

High

318046

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.437

High

318050

EYA3
Protein phosphatase EYA3

1

2

High-throughput

0.437

High

318059

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

6

Small-scale

0.437

High

318060

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.437

High

318061

EGLN3
Prolyl hydroxylase EGLN3

1

6

High-throughput

0.437

High

318069

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.437

High

318071

XPO7
Exportin-7

1

12

High-throughput

0.437

High

318073

TRI33
E3 ubiquitin-protein ligase TRIM33

1

10

High-throughput

0.437

High

294640

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

317969

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.426

High

318027

S39AB
Zinc transporter ZIP11

1

0

High-throughput

0.426

High

318045

SPTCS
Spatacsin

1

1

Small-scale

0.417

High

317997

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

12

High-throughput

0.407

High

318034

CTR3
Cationic amino acid transporter 3

1

4

High-throughput

0.407

High

318074

WDR37
WD repeat-containing protein 37

1

15

High-throughput

0.407

High

317963

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.282

High

317985

BTF3
Transcription factor BTF3

1

0

High-throughput

0.279

Low

318020

MSL1
Male-specific lethal 1 homolog

1

0

High-throughput

0.269

Low

318004

RL36A
Large ribosomal subunit protein eL42

1

0

High-throughput

0.249

Low

318007

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.249

Low

318014

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.249

Low

318039

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025