HitPredict

Interactor 1: LYN (P07948)
Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
Gene: LYN

Interactor 2: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0098978 - glutamatergic synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 512 Hs			1 1116
+	Hs
		440215 LCK_HUMAN (1-512): 0: 585: 63.62		PKHA5_HUMAN (1-1116): 0: 685: 100.00
+	Hs
		463588 LYN_HUMAN (1-512): 0: 621: 100.00		PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40
+	Hs
		440118 LCK_HUMAN (1-512): 0: 585: 63.62		PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40
+	Hs
		463129 YES_HUMAN (1-510): 0: 581: 54.26		PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40
+	Hs
		440251 LCK_HUMAN (1-512): 0: 585: 63.62		PKHA6_HUMAN (109-1116): 9.07e-88: 308: 28.41
+	Hs
		463458 LYN_HUMAN (1-512): 0: 621: 100.00		ANK2_HUMAN (261-1106): 2.88e-56: 216: 10.80
+	Hs
		463487 LYN_HUMAN (1-512): 0: 621: 100.00		ANK3_HUMAN (378-1098): 3e-50: 197: 11.71
+	Hs
		440126 LCK_HUMAN (1-512): 0: 585: 63.62		MPRIP_HUMAN (79-765): 7.82e-54: 206: 12.95
+	Hs
		440051 LCK_HUMAN (1-512): 0: 585: 63.62		ANK3_HUMAN (378-1098): 3e-50: 197: 11.71
+	Hs
		463776 LYN_HUMAN (1-512): 0: 621: 100.00		PKHA1_HUMAN (113-359): 3.29e-42: 161: 18.49
+	Dm
		1268534 SRC42_DROME (2-510): 0: 567: 49.13		Q7KNQ9_DROME (45-401): 9.43e-52: 201: 16.37
+	Hs
		463769 LYN_HUMAN (1-512): 0: 621: 100.00		PKHA4_HUMAN (142-450): 2.09e-34: 144: 25.94
+	Hs
		440210 LCK_HUMAN (1-512): 0: 585: 63.62		PKHA4_HUMAN (142-450): 2.09e-34: 144: 25.94
+	Hs
		440726 FYN_HUMAN (1-510): 0: 583: 54.31		PKHA4_HUMAN (142-450): 2.09e-34: 144: 25.94
+	Hs
		440678 FYN_HUMAN (1-510): 0: 583: 54.31		ITCH_HUMAN (11-246): 4.77e-29: 127: 16.95
+	Hs
		362376 ABL1_HUMAN (32-509): 1.52e-174: 523: 37.88		PKHA4_HUMAN (142-450): 2.09e-34: 144: 25.94
+	Hs
		834229 CSK_HUMAN (64-503): 1.56e-171: 493: 38.41		PKHA4_HUMAN (142-450): 2.09e-34: 144: 25.94