HitPredict

Interactor 1: 4F2 (P08195)
Amino acid transporter heavy chain SLC3A2 (4F2 cell-surface antigen heavy chain) (4F2hc) (4F2 heavy chain antigen) (Lymphocyte activation antigen 4F2 large subunit) (Solute carrier family 3 member 2) (CD antigen CD98)
Gene: SLC3A2

Interactor 2: LAT1 (Q01650)
Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain) (Integral membrane protein E16) (E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic amino acid transporter)
Gene: SLC7A5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.89 1.00 0.946

The method score is based on:

Property Details
Experiments 35271311, 9829974, 35575683, 30867591, unassigned3795, 31160781
Identification Methods affinity chromatography technology, cross-linking study, 3D electron microscopy, molecular sieving, anti tag coimmunoprecipitation, comigration in sds page
Interaction Type physical association, direct interaction, association, covalent binding

The annotation score is based on:

Property Details
Interacting Pfam domains AA_permease_2~Alpha-amylase, AA_permease_2~SLC3A2_N
Common GO terms GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0009925 - basal plasma membrane
GO:0015173 - aromatic amino acid transmembrane transporter activity
GO:0015175 - neutral L-amino acid transmembrane transporter activity
and 17 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 630
Hs

1 507
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Ce
+ Mm
+ Dm

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Last updated: 11Aug2025