HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: PRPK (Q96S44)
EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)
Gene: TP53RK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Hs			1 253
+	Hs
		169907 HS90B_HUMAN (1-724): 0: 1083: 100.00		AURKA_HUMAN (1-245): 1.99e-80: 248: 16.06
+	Hs
		169903 HS90A_HUMAN (1-724): 0: 1069: 85.25		AURKA_HUMAN (1-245): 1.99e-80: 248: 16.06
+	Hs
		468419 HS90B_HUMAN (1-724): 0: 1083: 100.00		KCC4_HUMAN (13-233): 1.87e-69: 222: 17.57
+	Hs
		461842 HS90A_HUMAN (1-724): 0: 1069: 85.25		PRPK_HUMAN (1-253): 9.36e-77: 234: 100.00
+	Hs
		461528 HS90A_HUMAN (1-724): 0: 1069: 85.25		KCC4_HUMAN (13-233): 1.87e-69: 222: 17.57
+	Hs
		468702 HS90B_HUMAN (1-724): 0: 1083: 100.00		KCC1G_HUMAN (33-191): 5.6e-26: 107: 17.90
+	Hs
		468008 HS90B_HUMAN (1-724): 0: 1083: 100.00		KPSH1_HUMAN (3-195): 8.03e-25: 103: 20.41
+	Hs
		468348 HS90B_HUMAN (1-724): 0: 1083: 100.00		KCC2D_HUMAN (28-187): 1.48e-21: 94.8: 18.41
+	Hs
		212631 HS90B_HUMAN (1-724): 0: 1083: 100.00		DAPK3_HUMAN (26-188): 2.65e-21: 94: 21.82
+	Hs
		468347 HS90B_HUMAN (1-724): 0: 1083: 100.00		KCC2G_HUMAN (28-187): 4e-21: 93.7: 18.18
+	Hs
		461827 HS90A_HUMAN (1-724): 0: 1069: 85.25		KCC1G_HUMAN (33-191): 5.6e-26: 107: 17.90
+	Hs
		461081 HS90A_HUMAN (1-724): 0: 1069: 85.25		KPSH1_HUMAN (3-195): 8.03e-25: 103: 20.41
+	Hs
		461301 HS90A_HUMAN (1-724): 0: 1069: 85.25		DAPK1_HUMAN (26-188): 3.83e-22: 97.1: 19.39
+	Hs
		461452 HS90A_HUMAN (1-724): 0: 1069: 85.25		KCC2D_HUMAN (28-187): 1.48e-21: 94.8: 18.41
+	Hs
		212630 HS90A_HUMAN (1-724): 0: 1069: 85.25		DAPK3_HUMAN (26-188): 2.65e-21: 94: 21.82
+	Hs
		461451 HS90A_HUMAN (1-724): 0: 1069: 85.25		KCC2G_HUMAN (28-187): 4e-21: 93.7: 18.18
+	Hs
		1158792 H90B3_HUMAN (1-724): 0: 815: 75.83		KCC4_HUMAN (13-233): 1.87e-69: 222: 17.57