Protein: DAPK3
Death-associated protein kinase 3 (DAP kinase 3) (EC 2.7.11.1) (DAP-like kinase) (Dlk) (MYPT1 kinase) (Zipper-interacting protein kinase) (ZIP-kinase)

Gene: DAPK3
Organism: Homo sapiens
Interactions: 90
UniProt ID: O43293

Gene Ontology (top 5):
GO:0000775 - chromosome, centromeric region
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

212619

DAPK3
Death-associated protein kinase 3

6

17

Small-scale

0.941

High

212667

CE170
Centrosomal protein of 170 kDa

3

8

High-throughput

0.861

High

212634

CDK2
Cyclin-dependent kinase 2

1

5

High-throughput

0.691

High

171122

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

5

Small-scale

0.690

High

212671

LUZP1
Leucine zipper protein 1

3

10

High-throughput

0.671

High

212659

GPS2
G protein pathway suppressor 2

4

0

High-throughput

0.661

High

212627

CHK2
Serine/threonine-protein kinase Chk2

1

16

Small-scale

0.647

High

212640

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.647

High

212655

KPCZ
Protein kinase C zeta type

1

5

Small-scale

0.647

High

212661

GRB14
Growth factor receptor-bound protein 14

1

17

Small-scale

0.647

High

212680

PAWR
PRKC apoptosis WT1 regulator protein

2

2

Small-scale

0.644

High

212636

TNR8
Tumor necrosis factor receptor superfamily member 8

2

2

High-throughput

0.628

High

212674

KIF2B
Kinesin-like protein KIF2B

2

2

High-throughput

0.628

High

156718

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.618

High

212621

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.618

High

212626

ULK1
Serine/threonine-protein kinase ULK1

1

19

Small-scale

0.618

High

212630

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

212631

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

212651

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.618

High

212662

KIF14
Kinesin-like protein KIF14

1

5

High-throughput

0.618

High

212664

CDC37
Hsp90 co-chaperone Cdc37

1

5

High-throughput

0.618

High

212687

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.618

High

212689

ANLN
Anillin

1

2

High-throughput

0.618

High

212691

NLK
Serine/threonine-protein kinase NLK

1

20

Small-scale

0.618

High

212695

TBK1
Serine/threonine-protein kinase TBK1

1

19

Small-scale

0.618

High

212699

NINL
Ninein-like protein

1

9

High-throughput

0.618

High

212675

TCP1L
T-complex protein 10A homolog 1

2

1

Small-scale

0.606

High

212688

EAF6
Chromatin modification-related protein MEAF6

2

0

High-throughput

0.602

High

212686

KLDC3
Kelch domain-containing protein 3

2

4

High-throughput

0.601

High

126380

RHOD
Rho-related GTP-binding protein RhoD

1

9

Small-scale

0.590

High

169026

ML12B
Myosin regulatory light chain 12B

1

20

Small-scale

0.575

High

212685

ZBT18
Zinc finger and BTB domain-containing protein 18

1

3

High-throughput

0.575

High

212654

UBE3A
Ubiquitin-protein ligase E3A

1

10

Small-scale

0.561

High

212620

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.552

High

212696

KAD3
GTP:AMP phosphotransferase AK3, mitochondrial

1

3

High-throughput

0.541

High

144208

ACACB
Acetyl-CoA carboxylase 2

1

4

High-throughput

0.536

High

212623

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

1

High-throughput

0.536

High

212633

FLNA
Filamin-A

1

14

High-throughput

0.536

High

212635

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

212637

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

212639

MYH9
Myosin-9

1

1

High-throughput

0.536

High

212642

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

10

High-throughput

0.536

High

212643

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

212644

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

212647

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

212648

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.536

High

212649

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.536

High

212653

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

212656

CALD1
Caldesmon

1

11

High-throughput

0.536

High

212658

ACACA
Acetyl-CoA carboxylase 1

1

4

High-throughput

0.536

High

212670

FLIP1
Filamin-A-interacting protein 1

1

11

High-throughput

0.536

High

212673

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

212677

MY18A
Unconventional myosin-XVIIIa

1

7

High-throughput

0.536

High

212679

MYO19
Unconventional myosin-XIX

1

11

High-throughput

0.536

High

212690

MYO5C
Unconventional myosin-Vc

1

7

High-throughput

0.536

High

212694

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

212645

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.518

High

212641

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.515

High

212657

CSTF3
Cleavage stimulation factor subunit 3

1

4

High-throughput

0.515

High

212692

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.515

High

185267

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.501

High

212629

P53
Cellular tumor antigen p53

1

4

Small-scale

0.501

High

212652

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.501

High

212676

LMO7
LIM domain only protein 7

1

4

Small-scale

0.501

High

212683

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

8

High-throughput

0.501

High

212625

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

20

High-throughput

0.489

High

212666

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

212632

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

3

Small-scale

0.479

High

212646

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

3

Small-scale

0.479

High

212663

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.479

High

212668

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.479

High

212669

CNTRL
Centriolin

1

4

High-throughput

0.479

High

212678

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

212684

RMD3
Regulator of microtubule dynamics protein 3

1

1

High-throughput

0.479

High

212693

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

212697

CC14A
Dual specificity protein phosphatase CDC14A

1

4

High-throughput

0.479

High

212698

COF2
Cofilin-2

1

7

High-throughput

0.479

High

212700

SNX9
Sorting nexin-9

1

1

High-throughput

0.479

High

212622

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.458

High

212624

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

212672

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.458

High

212638

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

212650

GRB2
Growth factor receptor-bound protein 2

1

13

High-throughput

0.445

High

212660

CTBP1
C-terminal-binding protein 1

1

3

High-throughput

0.445

High

212682

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.445

High

212628

ANXA1
Annexin A1

1

1

Small-scale

0.408

High

212681

C170L
Cep170-like protein

1

5

High-throughput

0.407

High

159106

ENPP3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3

1

0

High-throughput

0.269

Low

212665

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025