Protein: PRPK
EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase)

Gene: PRPK, TP53RK
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q96S44

Gene Ontology (top 5):
GO:0000408 - EKC/KEOPS complex
GO:0002039 - p53 binding
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1402184

TPRKB
EKC/KEOPS complex subunit TPRKB

11

1

Small-scale

0.982

High

1402179

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

7

1

Small-scale

0.751

High

1129261

LAGE3
EKC/KEOPS complex subunit LAGE3

5

1

Small-scale

0.716

High

1338912

NUP43
Nucleoporin Nup43

5

2

High-throughput

0.716

High

1402172

GON7
EKC/KEOPS complex subunit GON7

7

0

Small-scale

0.715

High

1095761

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

4

14

High-throughput

0.699

High

1402175

UBA5
Ubiquitin-like modifier-activating enzyme 5

3

2

High-throughput

0.662

High

1402180

MBIP1
MAP3K12-binding inhibitory protein 1

4

0

High-throughput

0.661

High

1369240

NELL1
Protein kinase C-binding protein NELL1

2

4

High-throughput

0.628

High

1402185

COMDA
COMM domain-containing protein 10

2

1

High-throughput

0.628

High

1205949

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

8

High-throughput

0.628

High

414455

P53
Cellular tumor antigen p53

2

5

Small-scale

0.595

High

914022

CHIO
Beta-chimaerin

2

5

High-throughput

0.576

High

294945

POP7
Ribonuclease P protein subunit p20

2

0

High-throughput

0.576

High

1402171

PAGR1
PAXIP1-associated glutamate-rich protein 1

2

0

High-throughput

0.576

High

1402178

GORS2
Golgi reassembly-stacking protein 2

2

1

High-throughput

0.553

High

1123778

DCTN1
Dynactin subunit 1

1

7

High-throughput

0.541

High

1338569

SYNE1
Nesprin-1

1

10

High-throughput

0.541

High

225670

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

6

High-throughput

0.536

High

483385

CLCB
Clathrin light chain B

1

1

High-throughput

0.536

High

1088984

TP53B
TP53-binding protein 1

1

2

High-throughput

0.536

High

1160256

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

4

High-throughput

0.536

High

1341089

INADL
InaD-like protein

1

9

High-throughput

0.536

High

1351017

DDX54
ATP-dependent RNA helicase DDX54

1

5

High-throughput

0.536

High

1402173

PDIP3
Polymerase delta-interacting protein 3

1

2

High-throughput

0.536

High

914062

SPSY
Spermine synthase

1

0

High-throughput

0.513

High

1402183

CYH4
Cytohesin-4

1

0

High-throughput

0.513

High

889486

CLK1
Dual specificity protein kinase CLK1

1

7

High-throughput

0.501

High

1028349

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.501

High

1402174

LRRC2
Leucine-rich repeat-containing protein 2

1

5

High-throughput

0.494

High

1336566

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

1

High-throughput

0.489

High

728394

AKT1
RAC-alpha serine/threonine-protein kinase

1

12

Small-scale

0.484

High

372910

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

461842

HS90A
Heat shock protein HSP 90-alpha

1

17

High-throughput

0.479

High

468715

HS90B
Heat shock protein HSP 90-beta

1

17

High-throughput

0.479

High

537752

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

589469

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

659566

CRCM
Colorectal mutant cancer protein

1

3

High-throughput

0.479

High

696277

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

768953

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

1007597

PRAME
Melanoma antigen preferentially expressed in tumors

1

1

Small-scale

0.479

High

1045672

TF65
Transcription factor p65

1

6

High-throughput

0.479

High

1100270

TIF1B
Transcription intermediary factor 1-beta

1

5

High-throughput

0.479

High

1255165

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

1276676

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

1402177

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.479

High

1402181

MTMRA
Myotubularin-related protein 10

1

3

High-throughput

0.479

High

1402182

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

879381

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

893731

MEOX1
Homeobox protein MOX-1

1

0

High-throughput

0.458

High

1402176

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.458

High

332571

CCDB1
Cyclin-D1-binding protein 1

1

1

High-throughput

0.457

High

391421

FRIL
Ferritin light chain

1

4

High-throughput

0.445

High

1367872

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

3

High-throughput

0.445

High

1326404

STX19
Syntaxin-19

1

5

High-throughput

0.437

High

1311511

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.426

High

1181208

ANO4
Anoctamin-4

2

0

High-throughput

0.313

High

1392001

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

377695

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1308134

LUR1L
Leucine rich adaptor protein 1-like

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025