HitPredict

Interactor 1: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Interactor 2: PEAK1 (Q9H792)
Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)
Gene: PEAK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37071682
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Hs			1 1746
+	Hs
		468278 HS90B_HUMAN (1-724): 0: 1083: 100.00		KPCE_HUMAN (1354-1719): 3.23e-92: 318: 13.98
+	Hs
		122904 HS90B_HUMAN (1-724): 0: 1083: 100.00		SGK1_HUMAN (1375-1741): 2.71e-94: 314: 12.47
+	Bt
		1030112 HS90B_BOVIN (1-724): 0: 1082: 99.59		AKT1_BOVIN (1362-1695): 1.51e-91: 308: 14.90
+	Hs
		468110 HS90B_HUMAN (1-724): 0: 1083: 100.00		AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07
+	Hs
		468928 HS90B_HUMAN (1-724): 0: 1083: 100.00		AKT3_HUMAN (1355-1695): 1.06e-90: 306: 14.33
+	Hs
		461373 HS90A_HUMAN (1-724): 0: 1069: 85.25		KPCE_HUMAN (1354-1719): 3.23e-92: 318: 13.98
+	Hs
		468042 HS90B_HUMAN (1-724): 0: 1083: 100.00		KAPCA_HUMAN (1345-1709): 1.11e-90: 301: 18.30
+	Hs
		122902 HS90A_HUMAN (1-724): 0: 1069: 85.25		SGK1_HUMAN (1375-1741): 2.71e-94: 314: 12.47
+	Hs
		461190 HS90A_HUMAN (1-724): 0: 1069: 85.25		AKT1_HUMAN (1362-1695): 4.45e-91: 307: 15.07
+	Hs
		461121 HS90A_HUMAN (1-724): 0: 1069: 85.25		KAPCA_HUMAN (1345-1709): 1.11e-90: 301: 18.30
+	Hs
		468760 HS90B_HUMAN (1-724): 0: 1083: 100.00		PINK1_HUMAN (1357-1669): 2.88e-73: 258: 23.64
+	Hs
		468507 HS90B_HUMAN (1-724): 0: 1083: 100.00		ULK3_HUMAN (1457-1691): 4.72e-56: 205: 21.85
+	Hs
		468702 HS90B_HUMAN (1-724): 0: 1083: 100.00		KCC1G_HUMAN (1453-1709): 6.73e-51: 190: 17.69
+	Hs
		468082 HS90B_HUMAN (1-724): 0: 1083: 100.00		KS6B1_HUMAN (1453-1683): 8.45e-45: 173: 16.17
+	Hs
		468074 HS90B_HUMAN (1-724): 0: 1083: 100.00		KAPCG_HUMAN (1452-1677): 6.19e-46: 171: 21.49
+	Hs
		461158 HS90A_HUMAN (1-724): 0: 1069: 85.25		KS6B1_HUMAN (1453-1683): 8.45e-45: 173: 16.17
+	Hs
		461152 HS90A_HUMAN (1-724): 0: 1069: 85.25		KAPCG_HUMAN (1452-1677): 6.19e-46: 171: 21.49
+	Hs
		468564 HS90B_HUMAN (1-724): 0: 1083: 100.00		PRAG1_HUMAN (1-91): 6.15e-28: 125: 40.43
+	Hs
		468204 HS90B_HUMAN (1-724): 0: 1083: 100.00		NEK4_HUMAN (1483-1657): 6.75e-12: 72.9: 21.91
+	Hs
		461294 HS90A_HUMAN (1-724): 0: 1069: 85.25		NEK4_HUMAN (1483-1657): 6.75e-12: 72.9: 21.91