HitPredict

Interactor 1: RAS1 (P08646)
Ras-like protein 1 (Dras1) (EC 3.6.5.2) (Dmras85D)
Gene: Ras85D

Interactor 2: KRAF1 (P11346)
Raf homolog serine/threonine-protein kinase Raf (D-Raf) (dRAF-1) (EC 2.7.11.1) (Protein pole-hole)
Gene: Raf

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.909

The method score is based on:

Property Details
Experiments 22500634, 20008569, 15723799, 15710747, unassigned4
Identification Methods affinity chromatography technology, two hybrid, two hybrid fragment pooling approach, experimental interaction detection
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains C1_1~Ras, PK_Tyr_Ser-Thr~Ras, RBD~Ras
Common GO terms GO:0000165 - MAPK cascade
GO:0002168 - instar larval development
GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0007265 - Ras protein signal transduction
and 23 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 189
Dm

1 739
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+ Ce

Service provided by Combinatics, Japan

Last updated: 11Aug2025