HitPredict

Interactor 1: NFIC (P08651)
Nuclear factor 1 C-type (NF1-C) (Nuclear factor 1/C) (CCAAT-box-binding transcription factor) (CTF) (Nuclear factor I/C) (NF-I/C) (NFI-C) (TGGCA-binding protein)
Gene: NFIC

Interactor 2: ISL2 (Q96A47)
Insulin gene enhancer protein ISL-2 (Islet-2)
Gene: ISL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	39617063
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II GO:1990837 - sequence-specific double-stranded DNA binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 359
+	Hs
		1133588 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		ISL2_HUMAN (1-359): 6.76e-85: 262: 100.00
+	Hs
		473861 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		LHX2_HUMAN (24-326): 9.55e-57: 191: 27.20
+	Hs
		1087925 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		ISL2_HUMAN (1-359): 6.76e-85: 262: 100.00
+	Hs
		473899 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Hs
		143176 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		ISL2_HUMAN (1-359): 6.76e-85: 262: 100.00
+	Hs
		965451 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Hs
		895710 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		LHX2_HUMAN (24-326): 9.55e-57: 191: 27.20
+	Hs
		965440 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Hs
		142898 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		LHX2_HUMAN (24-326): 9.55e-57: 191: 27.20
+	Hs
		142924 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		LMO4_HUMAN (15-165): 1.76e-54: 178: 38.13
+	Hs
		474184 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		474344 NFIC_HUMAN (1-508): 1.62e-162: 472: 100.00		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		1133583 NFIX_HUMAN (2-507): 2.18e-156: 456: 56.73		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		1087920 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		1088072 NFIA_HUMAN (2-508): 1.69e-133: 398: 59.20		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		143171 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		LHX4_HUMAN (1-82): 2.52e-17: 84.3: 22.89
+	Hs
		143304 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		LHX3_HUMAN (1-82): 1.49e-14: 76.2: 20.48
+	Hs
		142892 NFIB_HUMAN (1-423): 2.41e-128: 381: 63.47		LHX1_HUMAN (7-81): 3.85e-14: 75: 19.74
+	Hs
		895758 KMT2C_HUMAN (177-499): 7.46e-09: 60.7: 11.98		LHX2_HUMAN (24-326): 9.55e-57: 191: 27.20
+	Hs
		877533 KMT2C_HUMAN (177-499): 7.46e-09: 60.7: 11.98		LHX1_HUMAN (7-81): 3.85e-14: 75: 19.74