HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.965

The method score is based on:

Property Details
Experiments 17170710, 30017913, 16023600, 24143256, 18566590, 17290220, 19098711, 19166840
Identification Methods enzymatic study, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains ubiquitin~zf-C3HC4_3, ubiquitin~zf-RanBP
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0016567 - protein ubiquitination
and 2 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 685
Hs

1 491
+ Hs
+ Hs
+ Hs
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024