HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RIPK1 (Q13546)
Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Gene: RIPK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	25715336, 26017671, 25423073
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0010008 - endosome membrane GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 671
+	Hs
		201186 UBC_HUMAN (1-685): 0: 846: 100.00		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Hs
		337319 UBC_HUMAN (1-685): 0: 846: 100.00		ABL1_HUMAN (11-472): 1.06e-102: 340: 24.32
+	Hs
		201748 UBC_HUMAN (1-685): 0: 846: 100.00		RIPK2_HUMAN (60-306): 4.47e-30: 127: 32.96
+	Hs
		411563 UBC_HUMAN (1-685): 0: 846: 100.00		LCK_HUMAN (23-289): 1.31e-27: 119: 31.87
+	Hs
		923980 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		RIPK1_HUMAN (1-671): 0: 610: 100.00
+	At
		1092189 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		PERK1_ARATH (2-368): 3.58e-125: 387: 20.36
+	Mm
		476829 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		M3K7_MOUSE (4-611): 1.21e-120: 373: 19.12
+	Hs
		201174 ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69		M3K7_HUMAN (4-611): 9.44e-125: 384: 19.18
+	Rn
		989765 UBC_RAT (1-108): 1.27e-29: 127: 90.74		LYN_RAT (22-289): 5.94e-27: 117: 31.00
+	Hs
		475256 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		RIPK3_HUMAN (18-286): 1.57e-32: 134: 33.33
+	Hs
		435506 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		IGF1R_HUMAN (20-312): 1.02e-26: 118: 31.21