HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UBP10 (Q14694)
Ubiquitin carboxyl-terminal hydrolase 10 (EC 3.4.19.12) (Deubiquitinating enzyme 10) (Ubiquitin thioesterase 10) (Ubiquitin-specific-processing protease 10)
Gene: USP10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	29576527, 33141564, 34129829, 19398555, 23287719
Identification Methods	pull down, affinity chromatography technology, enzymatic study, unspecified method
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	UCH~ubiquitin
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 798
+	Hs
		475440 UBC_HUMAN (1-685): 0: 846: 100.00		UBP8_HUMAN (61-793): 7.74e-115: 376: 18.02
+	Hs
		271022 UBC_HUMAN (1-685): 0: 846: 100.00		UBP2_HUMAN (161-793): 7.79e-111: 352: 16.82
+	Hs
		476545 UBC_HUMAN (1-685): 0: 846: 100.00		UBP21_HUMAN (200-793): 7.22e-100: 322: 16.69
+	Hs
		476400 UBC_HUMAN (1-685): 0: 846: 100.00		UBP42_HUMAN (300-795): 2.8e-89: 309: 21.71
+	Hs
		476493 UBC_HUMAN (1-685): 0: 846: 100.00		UBP36_HUMAN (369-795): 4.36e-90: 309: 22.94
+	Hs
		259261 UBC_HUMAN (1-685): 0: 846: 100.00		UBP12_HUMAN (377-796): 1.48e-89: 288: 18.43
+	Hs
		476579 UBC_HUMAN (1-685): 0: 846: 100.00		UBP22_HUMAN (374-795): 4.81e-87: 287: 19.17
+	Hs
		475566 UBC_HUMAN (1-685): 0: 846: 100.00		UBP46_HUMAN (388-796): 1.7e-88: 285: 19.39
+	Hs
		476658 UBC_HUMAN (1-685): 0: 846: 100.00		UBP3_HUMAN (394-792): 1.31e-81: 272: 20.86
+	Hs
		475932 UBC_HUMAN (1-685): 0: 846: 100.00		U17L2_HUMAN (347-796): 2.97e-81: 271: 25.27
+	Hs
		64200 UBC_HUMAN (1-685): 0: 846: 100.00		UBP27_HUMAN (345-795): 2.62e-81: 269: 17.86
+	Dm
		477538 UBIQP_DROME (1-610): 0: 752: 99.84		NOT_DROME (385-794): 8.13e-82: 272: 20.90
+	At
		1210479 UBQ10_ARATH (305-685): 2.63e-153: 453: 95.80		UBP15_ARATH (175-795): 3.05e-84: 289: 17.83
+	Sc
		477413 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP3_YEAST (316-796): 3.78e-103: 340: 25.95
+	Sc
		477294 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP5_YEAST (229-795): 2.91e-84: 287: 18.06
+	Sc
		477366 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBP8_YEAST (416-797): 3.64e-85: 280: 23.66
+	At
		1092065 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBP15_ARATH (175-795): 3.05e-84: 289: 17.83
+	Mm
		476865 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP8_MOUSE (61-793): 1.85e-126: 406: 19.34
+	Hs
		924201 RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00		UBP36_HUMAN (369-795): 4.36e-90: 309: 22.94
+	Mm
		476741 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		UBP46_MOUSE (388-796): 1.7e-88: 285: 19.39