Interactor 1: IL6RA (P08887)
Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)]
Gene: IL6R
Interactor 2: SORL (Q92673)
Sortilin-related receptor (Low-density lipoprotein receptor relative with 11 ligand-binding repeats) (LDLR relative with 11 ligand-binding repeats) (LR11) (SorLA-1) (Sorting protein-related receptor containing LDLR class A repeats) (SorLA)
Gene: SORL1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.52 | 1.00 | 0.724 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28265003 |
| Identification Methods | surface plasmon resonance, cross-linking study |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | fn3~ig, IL6Ra-bind~fn3 |
| Common GO terms | GO:0005615 - extracellular space GO:0005886 - plasma membrane |
| Homologous interactions | 12 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
