HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37827155
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003684 - damaged DNA binding GO:0003697 - single-stranded DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006284 - base-excision repair and 1 others more... GO:0006310 - DNA recombination
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 616
+	Hs
		186622 HMGB3_HUMAN (13-181): 1.46e-41: 141: 71.60		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		695300 SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		318448 TOX4_HUMAN (91-163): 1.2e-27: 111: 38.36		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		694884 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		696270 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		604605 UBF1_HUMAN (10-158): 4.17e-09: 57.8: 23.60		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Sc
		547764 NHP6A_YEAST (75-164): 2.34e-23: 91.4: 45.56		RFA1_YEAST (4-615): 0: 596: 31.69
+	Sc
		547851 NHP6B_YEAST (73-164): 1.15e-21: 87.1: 42.39		RFA1_YEAST (4-615): 0: 596: 31.69