HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	38334954
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0017053 - transcription repressor complex GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 246
+	Hs
		481219 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		186636 HMGB3_HUMAN (13-181): 1.46e-41: 141: 71.60		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		481103 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		872154 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		872178 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		971907 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		1433E_HUMAN (3-243): 4.41e-144: 405: 65.43
+	Hs
		730170 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		1433B_HUMAN (1-246): 3.49e-144: 404: 100.00
+	Hs
		481190 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		990631 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		481120 HMGB1_HUMAN (1-174): 9.5e-45: 150: 100.00		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	Hs
		966241 SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		691354 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		1433T_HUMAN (3-244): 3.25e-127: 361: 81.82
+	Hs
		1049231 SSRP1_HUMAN (53-164): 1.6e-28: 114: 37.50		1433F_HUMAN (4-244): 2.72e-107: 311: 75.51
+	Hs
		872150 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		942085 SOX10_HUMAN (4-98): 2.08e-21: 93.2: 14.74		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		730446 SOX2_HUMAN (3-94): 7.23e-25: 100: 23.91		1433S_HUMAN (3-239): 3.4e-100: 293: 68.62
+	Hs
		966775 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		1433G_HUMAN (3-246): 1.92e-109: 317: 75.40
+	Hs
		1049692 CIC_HUMAN (3-96): 6.88e-12: 65.9: 22.34		1433F_HUMAN (4-244): 2.72e-107: 311: 75.51