HitPredict

Interactor 1: ANDR (P10275)
Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
Gene: AR

Interactor 2: SH2D3 (Q8N5H7)
SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1)
Gene: SH2D3C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 920 Hs			1 860
+	Hs
		433225 ANDR_HUMAN (1-920): 0: 966: 100.00		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		487088 ANDR_HUMAN (1-920): 0: 966: 100.00		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76
+	Hs
		454790 ANDR_HUMAN (1-920): 0: 966: 100.00		FGR_HUMAN (112-393): 2.09e-58: 210: 14.29
+	Hs
		487364 ANDR_HUMAN (1-920): 0: 966: 100.00		BTK_HUMAN (24-426): 1.81e-56: 208: 10.49
+	Hs
		426939 ANDR_HUMAN (1-920): 0: 966: 100.00		FES_HUMAN (1-394): 3.67e-54: 204: 18.75
+	Hs
		487245 ANDR_HUMAN (1-920): 0: 966: 100.00		BLK_HUMAN (108-394): 1.28e-54: 199: 13.44
+	Hs
		433537 ANDR_HUMAN (1-920): 0: 966: 100.00		LYN_HUMAN (132-424): 2.93e-54: 198: 11.39
+	Hs
		442764 ANDR_HUMAN (1-920): 0: 966: 100.00		HCK_HUMAN (91-394): 1.07e-53: 197: 13.71
+	Hs
		411564 ANDR_HUMAN (1-920): 0: 966: 100.00		LCK_HUMAN (123-424): 1.07e-53: 196: 10.59
+	Hs
		487621 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC3_HUMAN (8-322): 9.13e-53: 196: 20.99
+	Hs
		487535 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC4_HUMAN (8-321): 2.53e-52: 195: 18.67
+	Hs
		487216 ANDR_HUMAN (1-920): 0: 966: 100.00		CRK_HUMAN (209-512): 9.59e-54: 190: 16.06
+	Hs
		487683 ANDR_HUMAN (1-920): 0: 966: 100.00		HSH2D_HUMAN (219-535): 2.66e-51: 185: 16.31
+	Hs
		487512 ANDR_HUMAN (1-920): 0: 966: 100.00		SHE_HUMAN (83-322): 3.67e-48: 180: 20.00
+	Hs
		487161 ANDR_HUMAN (1-920): 0: 966: 100.00		SHC1_HUMAN (97-322): 5.53e-44: 170: 24.02
+	Hs
		487118 ANDR_HUMAN (1-920): 0: 966: 100.00		PLCG1_HUMAN (105-427): 7.42e-27: 120: 14.37
+	Hs
		487310 ANDR_HUMAN (1-920): 0: 966: 100.00		GRB2_HUMAN (214-310): 1.18e-27: 113: 27.00
+	Hs
		487153 ANDR_HUMAN (1-920): 0: 966: 100.00		P85A_HUMAN (202-319): 6.33e-16: 84.3: 22.58
+	Hs
		368834 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		YES_HUMAN (81-393): 4.07e-61: 218: 11.78
+	Hs
		368894 ESR1_HUMAN (378-904): 7.6e-136: 420: 22.20		SRC_HUMAN (20-393): 2.03e-60: 216: 12.76