HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.863

Property	Details
Experiments	12878163, 24728074, 9233773
Identification Methods	affinity chromatography technology, pull down, two hybrid, fluorescence polarization spectroscopy
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0008360 - regulation of cell shape GO:0030036 - actin cytoskeleton organization GO:0042169 - SH2 domain binding and 1 others more... GO:0060326 - cell chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 304
+	Hs
		499248 KIT_HUMAN (1-976): 0: 807: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Mm
		403536 KIT_MOUSE (1-975): 0: 773: 79.63		VAV_MOUSE (11-189): 7.04e-46: 167: 27.23
+	Hs
		499291 KIT_HUMAN (1-976): 0: 807: 100.00		VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15
+	Hs
		275165 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17
+	Hs
		499230 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		499228 KIT_HUMAN (1-976): 0: 807: 100.00		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		499253 KIT_HUMAN (1-976): 0: 807: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		499264 KIT_HUMAN (1-976): 0: 807: 100.00		GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67
+	Mm
		403541 KIT_MOUSE (1-975): 0: 773: 79.63		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		208982 KIT_HUMAN (1-976): 0: 807: 100.00		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		499225 KIT_HUMAN (1-976): 0: 807: 100.00		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		499283 KIT_HUMAN (1-976): 0: 807: 100.00		SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22
+	Mm
		292679 KIT_MOUSE (1-975): 0: 773: 79.63		GRAP2_MOUSE (18-192): 6.73e-14: 72.9: 19.79
+	Hs
		452371 PGFRB_HUMAN (30-954): 0: 591: 30.62		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		452342 PGFRB_HUMAN (30-954): 0: 591: 30.62		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Mm
		404014 PGFRB_MOUSE (14-974): 0: 597: 29.51		PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43
+	Hs
		452348 PGFRB_HUMAN (30-954): 0: 591: 30.62		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Mm
		404013 PGFRB_MOUSE (14-974): 0: 597: 29.51		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		208979 PGFRB_HUMAN (30-954): 0: 591: 30.62		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		452344 PGFRB_HUMAN (30-954): 0: 591: 30.62		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00