HitPredict

Interactor 1: PIM1 (P11309)
Serine/threonine-protein kinase pim-1 (EC 2.7.11.1)
Gene: PIM1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 0.60 0.656

The method score is based on:

Property Details
Experiments 19166854, 18467333
Identification Methods enzymatic study, affinity chromatography technology, pull down, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 3 others

more...
Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 313
Hs

1 491
+ Hs
+ Hs
+ Hs
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024