HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: RNF5 (Q99942)
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
Gene: RNF5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	12861019
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ubiquitin~zf-C3HC4_3
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 180
+	Hs
		508436 UBC_HUMAN (1-685): 0: 857: 100.00		RN185_HUMAN (17-179): 1.45e-49: 160: 60.98
+	Hs
		508813 UBC_HUMAN (1-685): 0: 857: 100.00		AMFR_HUMAN (8-171): 3.11e-28: 111: 16.27
+	Hs
		507891 UBC_HUMAN (1-685): 0: 857: 100.00		TRI26_HUMAN (15-146): 1.11e-26: 107: 19.15
+	Hs
		508670 UBC_HUMAN (1-685): 0: 857: 100.00		TRI39_HUMAN (18-146): 1.66e-25: 103: 20.00
+	Hs
		507515 UBC_HUMAN (1-685): 0: 857: 100.00		RO52_HUMAN (23-148): 2.34e-23: 97.5: 18.11
+	Hs
		508576 UBC_HUMAN (1-685): 0: 857: 100.00		TRIM5_HUMAN (14-146): 2.05e-23: 97.5: 20.29
+	Hs
		507972 UBC_HUMAN (1-685): 0: 857: 100.00		HLTF_HUMAN (20-77): 1.47e-20: 89.8: 29.31
+	Hs
		508823 UBC_HUMAN (1-685): 0: 857: 100.00		CBLC_HUMAN (6-93): 1.27e-19: 86.7: 28.28
+	Hs
		507625 UBC_HUMAN (1-685): 0: 857: 100.00		BRCA1_HUMAN (25-76): 2.76e-19: 86.4: 34.62
+	Xl
		1220161 Q7SY79_XENLA (77-685): 0: 752: 99.84		Q5XGX4_XENLA (2-179): 1.09e-53: 170: 56.67
+	Xl
		1274149 Q7SY79_XENLA (77-685): 0: 752: 99.84		NF7B_XENLA (4-119): 6.36e-25: 102: 18.49
+	Dm
		1305897 Q9W418_DROME (229-685): 0: 567: 99.78		Q8IR26_DROME (3-179): 4.44e-50: 164: 48.32
+	Dm
		1488374 R9PY16_DROME (457-685): 1.03e-83: 268: 90.39		Q9VXP1_DROME (3-178): 1.4e-54: 175: 47.73
+	Dm
		1305899 R9PY16_DROME (457-685): 1.03e-83: 268: 90.39		Q8IR26_DROME (3-179): 4.44e-50: 164: 48.32
+	At
		1167946 UBQ3_ARATH (457-685): 4e-89: 282: 95.63		SM3L1_ARATH (21-76): 4.45e-11: 62.4: 25.00
+	Xl
		1220156 Q6GMC1_XENLA (609-684): 7.26e-41: 148: 100.00		Q5XGX4_XENLA (2-179): 1.09e-53: 170: 56.67
+	Hs
		987161 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		RN185_HUMAN (17-179): 1.45e-49: 160: 60.98
+	Hs
		987263 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		AMFR_HUMAN (8-171): 3.11e-28: 111: 16.27
+	Hs
		987200 RS27A_HUMAN (609-684): 7.26e-41: 148: 100.00		TRI31_HUMAN (19-126): 3.93e-25: 102: 20.91
+	Mm
		508974 UBC_MOUSE (1-108): 2.12e-30: 129: 90.74		BRCA1_MOUSE (25-76): 7.63e-19: 85.2: 34.62