HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: TOPRS (Q9NS56)
E3 ubiquitin-protein ligase Topors (EC 2.3.2.27) (RING-type E3 ubiquitin transferase Topors) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3)
Gene: TOPORS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	10352183, 20805487, 17976381
Identification Methods	affinity chromatography technology, two hybrid, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 1045
+	Dm
		672632 TOP1_DROME (30-765): 0: 854: 55.56		TOPRS_DROME (54-665): 5.9e-125: 408: 23.07
+	Hs
		508571 TOP1_HUMAN (1-765): 0: 932: 100.00		NIPBL_HUMAN (362-1016): 7.16e-73: 267: 13.73
+	Hs
		508676 TOP1_HUMAN (1-765): 0: 932: 100.00		SCAFB_HUMAN (465-951): 2.34e-12: 73.5: 13.03
+	Hs
		1154038 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		NIPBL_HUMAN (362-1016): 7.16e-73: 267: 13.73
+	Ce
		136802 UNC89_CAEEL (3-197): 4.06e-15: 82.1: 20.47		UNC22_CAEEL (500-955): 3.2e-10: 67: 10.49
+	Pf
		86917 C6KT30_PLAF7 (2-196): 2.12e-11: 69.8: 16.08		Q8I3A0_PLAF7 (555-948): 1.07e-11: 71.6: 10.22