HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005730 - nucleolus GO:0019904 - protein domain specific binding GO:0032922 - circadian regulation of gene expression
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 323
+	Hs
		508426 TOP1_HUMAN (1-765): 0: 932: 100.00		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		508427 TOP1_HUMAN (1-765): 0: 932: 100.00		PP1B_HUMAN (1-322): 0: 560: 86.89