HitPredict

Interactor 1: BMP2 (P12643)
Bone morphogenetic protein 2 (BMP-2) (Bone morphogenetic protein 2A) (BMP-2A)
Gene: BMP2

Interactor 2: RGMB (Q6NW40)
Repulsive guidance molecule B (DRG11-responsive axonal guidance and outgrowth of neurite) (DRAGON)
Gene: RGMB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.820

Property	Details
Experiments	15671031, 25938661
Identification Methods	pull down, molecular sieving, light scattering, x-ray crystallography, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RGM_C~TGF_beta, RGM_N~TGF_beta
Common GO terms	GO:0030509 - BMP signaling pathway GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 396 Hs			1 437
+	Hs
		520161 BMP4_HUMAN (1-396): 4.38e-142: 411: 60.49		RGMB_HUMAN (1-437): 0: 645: 100.00
+	Hs
		520085 BMP2_HUMAN (1-396): 1.08e-165: 471: 100.00		RGMA_HUMAN (24-425): 0: 530: 49.18
+	Hs
		520082 BMP2_HUMAN (1-396): 1.08e-165: 471: 100.00		RGMC_HUMAN (49-435): 4.01e-173: 493: 41.83
+	Hs
		602933 BMP6_HUMAN (51-395): 6.17e-104: 318: 27.07		RGMC_HUMAN (49-435): 4.01e-173: 493: 41.83
+	Mm
		982857 INHBB_MOUSE (28-395): 3.94e-96: 294: 24.47		RGMC_MOUSE (49-437): 9.54e-176: 499: 41.26
+	Ce
		106033 DBL1_CAEEL (52-396): 3.47e-75: 239: 27.50		RGMB_CAEEL (52-407): 1.1e-138: 404: 29.86