HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24550280
Identification Methods	phage display
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005911 - cell-cell junction GO:0030054 - cell junction GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 1630
+	Hs
		211579 ACTN4_HUMAN (11-892): 0: 642: 86.74		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		993251 ACTN3_HUMAN (18-892): 0: 642: 78.51		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		725654 ACTN2_HUMAN (10-892): 0: 640: 80.29		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Mm
		49891 A1BN54_MOUSE (1-892): 0: 684: 97.20		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		725643 ACTN2_HUMAN (10-892): 0: 640: 80.29		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Mm
		885081 ACTN4_MOUSE (11-892): 0: 639: 86.74		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		521600 ACTN1_HUMAN (1-892): 0: 697: 100.00		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Hs
		725649 ACTN2_HUMAN (10-892): 0: 640: 80.29		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Hs
		725690 ACTN2_HUMAN (10-892): 0: 640: 80.29		ERBIN_HUMAN (816-952): 8.76e-12: 72.8: 28.06
+	Mm
		1143324 SPTB2_MOUSE (196-761): 1.13e-14: 81.2: 12.88		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42