HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.50	0.569

Property	Details
Experiments	29509190, 21182203, 25604459
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 530
+	Hs
		368893 ACTN1_HUMAN (1-892): 0: 697: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		211633 ACTN4_HUMAN (11-892): 0: 642: 86.74		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		993279 ACTN3_HUMAN (18-892): 0: 642: 78.51		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211456 ACTN4_HUMAN (11-892): 0: 642: 86.74		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		521532 ACTN1_HUMAN (1-892): 0: 697: 100.00		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		211472 ACTN4_HUMAN (11-892): 0: 642: 86.74		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Mm
		580490 ACTN2_MOUSE (10-892): 0: 643: 80.63		ANDR_MOUSE (149-407): 1.53e-38: 152: 33.70
+	Hs
		211471 ACTN4_HUMAN (11-892): 0: 642: 86.74		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		164649 SPTN2_HUMAN (225-763): 1.02e-15: 84.3: 14.42		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369420 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		320227 SPTN4_HUMAN (173-588): 8.58e-09: 62: 10.82		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57