HitPredict

Interactor 1: CG13 (P13365)
G1/S-specific cyclin CLN3
Gene: CLN3

Interactor 2: PHO85 (P17157)
Cyclin-dependent protein kinase PHO85 (EC 2.7.11.22) (Negative regulator of the PHO system) (Serine/threonine-protein kinase PHO85)
Gene: PHO85

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	23339867, 23217712
Identification Methods	enzymatic study, protein kinase assay
Interaction Type	direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	Cyclin_N~Pkinase
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 580 Sc			1 305
+	Sc
		339395 CG13_YEAST (1-580): 0: 539: 100.00		CDK1_YEAST (6-299): 5.63e-128: 368: 52.17
+	Hs
		625350 CCNA1_HUMAN (3-343): 1.07e-100: 314: 14.87		CDK2_HUMAN (4-303): 7.49e-145: 410: 54.82
+	At
		621689 CCA32_ARATH (1-333): 1.18e-107: 329: 13.78		CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17
+	At
		621697 CCA31_ARATH (1-333): 8.84e-104: 319: 15.47		CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17
+	At
		48929 CCA33_ARATH (38-332): 2.03e-102: 314: 13.38		CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17
+	At
		1319943 CCA32_ARATH (1-333): 1.18e-107: 329: 13.78		CDKD1_ARATH (3-304): 4.46e-128: 372: 37.29
+	Hs
		414855 CCNA1_HUMAN (3-343): 1.07e-100: 314: 14.87		CDK1_HUMAN (4-300): 1.59e-135: 387: 50.00
+	At
		621662 CCA21_ARATH (3-333): 1.1e-99: 311: 15.66		CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17
+	At
		621664 CCA34_ARATH (1-333): 3.66e-100: 310: 12.46		CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17
+	At
		621661 CCB12_ARATH (2-355): 5.84e-99: 309: 17.50		CDKA1_ARATH (4-300): 4.44e-136: 388: 51.17
+	At
		1108309 CCA34_ARATH (1-333): 3.66e-100: 310: 12.46		Q9CAG1_ARATH (3-305): 1.91e-128: 384: 40.78
+	At
		1103369 CCA31_ARATH (1-333): 8.84e-104: 319: 15.47		CKB12_ARATH (4-302): 8.93e-127: 365: 45.54
+	At
		1227954 CCA31_ARATH (1-333): 8.84e-104: 319: 15.47		CKB21_ARATH (1-305): 1.26e-126: 365: 41.53
+	At
		1108308 CCA34_ARATH (1-333): 3.66e-100: 310: 12.46		CDKD1_ARATH (3-304): 4.46e-128: 372: 37.29
+	At
		1106926 CCB13_ARATH (2-346): 3.83e-101: 314: 16.23		CDKD2_ARATH (4-304): 1.13e-126: 366: 37.75
+	At
		1103352 CCA21_ARATH (3-333): 1.1e-99: 311: 15.66		CKB12_ARATH (4-302): 8.93e-127: 365: 45.54
+	At
		1106945 CCA21_ARATH (3-333): 1.1e-99: 311: 15.66		CKB21_ARATH (1-305): 1.26e-126: 365: 41.53
+	At
		1103353 CCA34_ARATH (1-333): 3.66e-100: 310: 12.46		CKB12_ARATH (4-302): 8.93e-127: 365: 45.54
+	At
		1108302 CCA34_ARATH (1-333): 3.66e-100: 310: 12.46		CKB21_ARATH (1-305): 1.26e-126: 365: 41.53
+	At
		1103350 CCB12_ARATH (2-355): 5.84e-99: 309: 17.50		CKB12_ARATH (4-302): 8.93e-127: 365: 45.54