Protein: HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial (EC 3.6.4.10) (Heat shock protein SSQ1, mitochondrial) (Stress-seventy subfamily Q protein 1) (mtHSP70 homolog)

Gene: HSP7Q, SSQ1
Organism: Saccharomyces cerevisiae S288C
Interactions: 126
UniProt ID: Q05931

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006879 - intracellular iron ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800364

GRPE
GrpE protein homolog, mitochondrial

3

6

Small-scale

0.861

High

510828

HSP77
Import motor subunit, mitochondrial

3

18

Small-scale

0.827

High

1040576

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

5

6

Small-scale

0.714

High

918089

JAC1
J-type co-chaperone JAC1, mitochondrial

1

2

Small-scale

0.647

High

525176

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.575

High

527701

HSP72
Heat shock protein SSA2

1

17

High-throughput

0.575

High

546310

SSB1
Ribosome-associated molecular chaperone SSB1

1

20

High-throughput

0.575

High

804463

SSZ1
Ribosome-associated complex subunit SSZ1

1

14

High-throughput

0.575

High

657201

GYS1
Glycogen [starch] synthase isoform 1

1

4

High-throughput

0.536

High

708209

TF2B
Transcription initiation factor IIB

2

8

High-throughput

0.521

High

817055

ISC1
Inositol phosphosphingolipids phospholipase C

1

1

Small-scale

0.501

High

676979

SRO9
RNA-binding protein SRO9

1

13

High-throughput

0.489

High

1047279

ERB1
Ribosome biogenesis protein ERB1

1

12

High-throughput

0.489

High

383001

RMAR
Small ribosomal subunit protein uS3m

1

4

High-throughput

0.479

High

595000

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

604976

MDHM
Malate dehydrogenase, mitochondrial

1

10

High-throughput

0.479

High

673532

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

13

High-throughput

0.479

High

735564

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

12

High-throughput

0.479

High

741121

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

7

High-throughput

0.479

High

746947

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

6

High-throughput

0.479

High

752742

HSP78
Heat shock protein 78, mitochondrial

1

19

High-throughput

0.479

High

817507

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

15

High-throughput

0.479

High

856568

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

15

High-throughput

0.479

High

1033455

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

5

Small-scale

0.479

High

1038588

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

5

Small-scale

0.479

High

1049984

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

4

High-throughput

0.479

High

1052944

ISU2
Iron sulfur cluster assembly protein 2, mitochondrial

1

6

High-throughput

0.479

High

394914

EF1A
Elongation factor 1-alpha

1

6

High-throughput

0.445

High

408353

GAL1
Galactokinase

1

5

High-throughput

0.445

High

432365

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

4

High-throughput

0.445

High

449008

TOP2
DNA topoisomerase 2

1

10

High-throughput

0.445

High

452532

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

3

High-throughput

0.445

High

464342

OAT
Ornithine aminotransferase

1

5

High-throughput

0.445

High

586023

CSK21
Casein kinase II subunit alpha

1

20

High-throughput

0.445

High

633511

PP11
Serine/threonine-protein phosphatase PP1-1

1

20

High-throughput

0.445

High

647225

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

9

High-throughput

0.445

High

647838

RFA1
Replication factor A protein 1

1

7

High-throughput

0.445

High

660817

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

20

High-throughput

0.445

High

664468

MCM3
DNA replication licensing factor MCM3

1

20

High-throughput

0.445

High

678530

TAH1
TPR repeat-containing protein associated with Hsp90

1

20

High-throughput

0.445

High

732785

CHMU
Chorismate mutase

1

3

High-throughput

0.445

High

735867

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

12

High-throughput

0.445

High

743647

RTG2
Retrograde regulation protein 2

1

4

High-throughput

0.445

High

744562

FADH
S-(hydroxymethyl)glutathione dehydrogenase

1

15

High-throughput

0.445

High

750207

UFD4
Ubiquitin fusion degradation protein 4

1

19

High-throughput

0.445

High

775990

TCTP
Translationally-controlled tumor protein homolog

1

6

High-throughput

0.445

High

781066

T2EA
Transcription initiation factor IIE subunit alpha

1

2

High-throughput

0.445

High

790293

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

7

High-throughput

0.445

High

795924

LSM2
LSM complex subunit LSM2

1

7

High-throughput

0.445

High

803689

RPN1
26S proteasome regulatory subunit RPN1

1

11

High-throughput

0.445

High

807925

BFR1
Nuclear segregation protein BFR1

1

2

High-throughput

0.445

High

808817

SHC1
Protein SHC1

1

9

High-throughput

0.445

High

814276

RV167
Reduced viability upon starvation protein 167

1

20

High-throughput

0.445

High

815063

SNF7
Vacuolar-sorting protein SNF7

1

13

High-throughput

0.445

High

820840

RUXG
Small nuclear ribonucleoprotein G

1

9

High-throughput

0.445

High

825365

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

11

High-throughput

0.445

High

828277

SYA
Alanine--tRNA ligase, mitochondrial

1

13

High-throughput

0.445

High

828511

SA185
SIT4-associating protein SAP185

1

10

High-throughput

0.445

High

864519

MTR4
ATP-dependent RNA helicase DOB1

1

20

High-throughput

0.445

High

865073

TCPQ
T-complex protein 1 subunit theta

1

10

High-throughput

0.445

High

866227

MET5
Sulfite reductase [NADPH] subunit beta

1

9

High-throughput

0.445

High

877909

VATG
V-type proton ATPase subunit G

1

6

High-throughput

0.445

High

881821

LYS4
Homoaconitase, mitochondrial

1

18

High-throughput

0.445

High

915249

ACS2
Acetyl-coenzyme A synthetase 2

1

6

High-throughput

0.445

High

916912

APC10
Anaphase-promoting complex subunit DOC1

1

3

High-throughput

0.445

High

917322

INO80
Chromatin-remodeling ATPase INO80

1

20

High-throughput

0.445

High

924388

FMP41
Oxaloacetate tautomerase FMP41, mitochondrial

1

2

High-throughput

0.445

High

924452

NSG2
Protein NSG2

1

4

High-throughput

0.445

High

1030545

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

17

High-throughput

0.445

High

1033890

PRS8
26S proteasome regulatory subunit 8 homolog

1

12

High-throughput

0.445

High

1046501

ARMT1
Damage-control phosphatase YMR027W

1

2

High-throughput

0.445

High

1052939

IWR1
RNA polymerase II nuclear localization protein IWR1

1

3

High-throughput

0.445

High

1052940

FRDA
Frataxin homolog, mitochondrial

1

1

Small-scale

0.445

High

1052943

LKHA4
Leucine aminopeptidase 2

1

11

High-throughput

0.445

High

1052946

RPIA
Ribose-5-phosphate isomerase

1

2

High-throughput

0.445

High

1052947

RUXE
Small nuclear ribonucleoprotein E

1

3

High-throughput

0.445

High

1052949

TCB1
Tricalbin-1

1

11

High-throughput

0.445

High

1052948

ERP3
Protein ERP3

1

15

High-throughput

0.439

High

748546

SC61A
Protein transport protein SEC61

1

3

High-throughput

0.437

High

1044124

MSS11
Transcription activator MSS11

1

0

High-throughput

0.426

High

1052938

BL1S4
Biogenesis of lysosome-related organelles complex 1 subunit CNL1

1

0

High-throughput

0.426

High

432921

RL9A
Large ribosomal subunit protein uL6A

1

7

High-throughput

0.407

High

511346

RL43A
Large ribosomal subunit protein eL43A

1

2

High-throughput

0.407

High

660241

AATC
Aspartate aminotransferase, cytoplasmic

1

5

High-throughput

0.407

High

673228

RRP7
Ribosomal RNA-processing protein 7

1

1

High-throughput

0.407

High

699972

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

6

High-throughput

0.407

High

700046

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

5

High-throughput

0.407

High

721278

PSB5
Proteasome subunit beta type-5

1

9

High-throughput

0.407

High

734208

EF2
Elongation factor 2

1

14

High-throughput

0.407

High

736732

ASF1
Histone chaperone ASF1

1

3

High-throughput

0.407

High

737777

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

16

High-throughput

0.407

High

740225

RPN2
26S proteasome regulatory subunit RPN2

1

11

High-throughput

0.407

High

740757

SRP40
Suppressor protein SRP40

1

5

High-throughput

0.407

High

740812

MED18
Mediator of RNA polymerase II transcription subunit 18

1

5

High-throughput

0.407

High

748307

SPT4
Transcription elongation factor SPT4

1

2

High-throughput

0.407

High

780386

ELF1
Transcription elongation factor 1

1

2

High-throughput

0.407

High

781691

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

3

High-throughput

0.407

High

794001

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

14

High-throughput

0.407

High

799772

IF5
Eukaryotic translation initiation factor 5

1

6

High-throughput

0.407

High

805527

ORC6
Origin recognition complex subunit 6

1

4

High-throughput

0.407

High

816180

DPO5
rDNA transcriptional regulator POL5

1

4

High-throughput

0.407

High

823602

RIC1
Guanine nucleotide exchange factor subunit RIC1

1

3

High-throughput

0.407

High

849897

IES1
Ino eighty subunit 1

1

2

High-throughput

0.407

High

865753

MOG1
Nuclear import protein MOG1

1

4

High-throughput

0.407

High

865848

EAF6
Chromatin modification-related protein EAF6

1

2

High-throughput

0.407

High

866258

HIR3
Histone transcription regulator 3

1

2

High-throughput

0.407

High

893342

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

10

High-throughput

0.407

High

898195

SPT20
SAGA complex subunit SPT20

1

4

High-throughput

0.407

High

916841

MNT2
Alpha-1,3-mannosyltransferase MNT2

1

10

High-throughput

0.407

High

918823

UTP22
U3 small nucleolar RNA-associated protein 22

1

2

High-throughput

0.407

High

918872

DRN1
CWF19-like protein DRN1

1

2

High-throughput

0.407

High

918893

RRP46
Exosome complex component RRP46

1

9

High-throughput

0.407

High

922121

COPA
Coatomer subunit alpha

1

18

High-throughput

0.407

High

924588

EAF7
Chromatin modification-related protein EAF7

1

6

High-throughput

0.407

High

963722

H3
Histone H3

1

16

High-throughput

0.407

High

1046513

PUF6
Pumilio homology domain family member 6

1

14

High-throughput

0.407

High

1051562

RT103
Regulator of Ty1 transposition protein 103

1

5

High-throughput

0.407

High

1051708

RRP45
Exosome complex component RRP45

1

11

High-throughput

0.407

High

1052937

PDP3
NuA3 HAT complex component PDP3

1

2

High-throughput

0.407

High

1052941

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

18

High-throughput

0.407

High

1052942

THP1
Nuclear mRNA export protein THP1

1

5

High-throughput

0.407

High

1052945

MAK21
Ribosome biogenesis protein MAK21

1

8

High-throughput

0.407

High

1052950

EFG1P
rRNA-processing protein EFG1

1

3

High-throughput

0.407

High

1052951

ATG40
Autophagy-related protein 40

1

2

High-throughput

0.407

High

585375

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.307

High

749727

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025