HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: DSG1 (Q02413)
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)
Gene: DSG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31324722, 22038833
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1049
+	Hs
		529095 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DSG2_HUMAN (2-1048): 0: 742: 32.40
+	Hs
		529034 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DSC1_HUMAN (29-765): 0: 574: 24.87
+	Hs
		528838 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CAD13_HUMAN (42-590): 4.77e-155: 478: 27.06
+	Hs
		521697 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CADH1_HUMAN (19-485): 8.8e-59: 220: 19.01
+	Hs
		529910 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PCDB8_HUMAN (433-1004): 1.17e-39: 160: 11.22
+	Hs
		528548 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CADH3_HUMAN (13-185): 1.95e-13: 77: 17.03