HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: AT2B4 (P23634)
Plasma membrane calcium-transporting ATPase 4 (PMCA4) (EC 7.2.2.10) (Matrix-remodeling-associated protein 1) (Plasma membrane calcium ATPase isoform 4) (Plasma membrane calcium pump isoform 4)
Gene: ATP2B4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35063084
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005886 - plasma membrane GO:0010629 - negative regulation of gene expression GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 1241
+	Hs
		529054 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AT2B1_HUMAN (1-1241): 0: 1149: 72.46
+	Mm
		104758 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		F7AAP4_MOUSE (1-1144): 0: 1123: 86.20
+	Mm
		530868 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		Q8C048_MOUSE (1-1103): 0: 1114: 78.13
+	Mm
		237216 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		AT2A2_MOUSE (45-1066): 0: 832: 27.01
+	Hs
		528974 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AT1A3_HUMAN (27-1060): 0: 764: 24.32
+	Hs
		420317 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AT1A1_HUMAN (30-1060): 0: 759: 23.78
+	Hs
		529367 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AT1A2_HUMAN (35-1060): 0: 747: 23.52
+	Hs
		529015 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AT2A2_HUMAN (45-1067): 0: 735: 25.87
+	Rn
		444693 TAU_RAT (1-758): 3.21e-76: 263: 72.11		AT1A1_RAT (30-1060): 0: 761: 23.60
+	Rn
		98646 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		AT1A1_RAT (30-1060): 0: 761: 23.60
+	Rn
		444715 TAU_RAT (1-758): 3.21e-76: 263: 72.11		AT1A3_RAT (34-1060): 0: 752: 23.57
+	Rn
		98648 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		AT1A3_RAT (34-1060): 0: 752: 23.57
+	Rn
		444707 TAU_RAT (1-758): 3.21e-76: 263: 72.11		AT1A2_RAT (35-1060): 0: 745: 23.43
+	Rn
		98647 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		AT1A2_RAT (35-1060): 0: 745: 23.43
+	Rn
		547300 TAU_RAT (1-758): 3.21e-76: 263: 72.11		AT2A2_RAT (45-1066): 0: 734: 25.89
+	Rn
		98665 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		AT2A2_RAT (45-1066): 0: 734: 25.89
+	Hs
		598085 MDC1_HUMAN (31-732): 1.31e-18: 93.5: 10.48		AT2A2_HUMAN (45-1067): 0: 735: 25.87
+	Hs
		420666 CIC_HUMAN (10-717): 9.83e-10: 64.7: 8.46		AT1A1_HUMAN (30-1060): 0: 759: 23.78