HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MY18A (Q92614)
Unconventional myosin-XVIIIa (Molecule associated with JAK3 N-terminus) (MAJN) (Myosin containing a PDZ domain) (Surfactant protein receptor SP-R210) (SP-R210)
Gene: MYO18A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	26618866, 31324722, 29924966
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0009986 - cell surface GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 2054
+	Hs
		529896 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH13_HUMAN (1051-1986): 4.14e-54: 212: 13.75
+	Hs
		528400 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH8_HUMAN (1116-1997): 2.71e-53: 209: 14.76
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (1141-2053): 1.27e-51: 204: 13.34
+	Hs
		502902 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH3_HUMAN (1134-2052): 4.44e-51: 202: 15.52
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (1141-1989): 2.8e-46: 186: 14.96
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (954-1819): 2.95e-41: 169: 12.80
+	Hs
		522533 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH1_HUMAN (959-1794): 5.17e-37: 156: 9.50
+	Hs
		529972 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH4_HUMAN (976-1822): 6.83e-37: 155: 13.06
+	Hs
		529895 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH2_HUMAN (1056-1724): 7.97e-34: 145: 11.11
+	Hs
		529767 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5C_HUMAN (1119-1615): 4.36e-24: 113: 12.21
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (1684-2053): 3.04e-19: 97.5: 15.00
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (1178-1641): 2.73e-18: 94.4: 14.56
+	Hs
		64579 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7B_HUMAN (1189-1597): 2.3e-16: 88.3: 10.98
+	Hs
		529903 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5B_HUMAN (1603-2051): 4.65e-14: 80.6: 9.19
+	Hs
		529959 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5A_HUMAN (1789-2053): 7.86e-13: 76.7: 12.84
+	Hs
		529340 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH14_HUMAN (1253-1933): 3.46e-11: 71.2: 19.08