HitPredict

Interactor 1: ITA4 (P13612)
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Gene: ITGA4

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	11533025, 11919182, 21173240, 10604475
Identification Methods	pull down, anti bait coimmunoprecipitation, affinity chromatography technology
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0034446 - substrate adhesion-dependent cell spreading GO:0046872 - metal ion binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1032 Hs			1 591
+	Hs
		238945 ITA4_HUMAN (1-1032): 0: 1246: 100.00		LPXN_HUMAN (186-590): 2.88e-109: 334: 50.37
+	Hs
		200158 ITA4_HUMAN (1-1032): 0: 1246: 100.00		TGFI1_HUMAN (1-532): 4.62e-63: 216: 24.91
+	Hs
		419175 ITAV_HUMAN (31-1007): 0: 862: 25.46		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		1044588 ITA7_HUMAN (1-1009): 0: 863: 24.52		FHL3_HUMAN (382-590): 1.13e-57: 196: 28.64
+	Hs
		1044819 ITA7_HUMAN (1-1009): 0: 863: 24.52		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Hs
		639888 ITA3_HUMAN (1-1021): 0: 818: 22.87		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87
+	Mm
		1307899 ITA2B_MOUSE (27-1012): 0: 774: 26.20		LPXN_MOUSE (343-415): 1.39e-11: 68.4: 35.62
+	Ce
		107579 PAT2_CAEEL (33-886): 0: 708: 23.67		G5EFG1_CAEEL (473-590): 4.79e-32: 133: 35.00
+	Mm
		1208581 ITA2B_MOUSE (27-1012): 0: 774: 26.20		PDLI5_MOUSE (530-590): 7.68e-11: 66.9: 34.43
+	Hs
		566880 ITA2_HUMAN (27-183): 2.04e-34: 145: 28.30		FHL2_HUMAN (329-467): 4.35e-25: 107: 25.87