HitPredict

Interactor 1: IRF1 (P10914)
Interferon regulatory factor 1 (IRF-1)
Gene: IRF1

Interactor 2: C2TA (P33076)
MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)
Gene: CIITA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.751

Property	Details
Experiments	12493643, 11675374, 9916712, 12788988, 12052885, 17300840, 16982896, 15950283, 10557076, 16195385, 18500344
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060333 - type II interferon-mediated signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 325 Hs			1 1130
+	Mm
		583143 IRF1_MOUSE (1-325): 2.48e-161: 455: 84.50		C2TA_MOUSE (19-1130): 0: 904: 70.53
+	Hs
		749469 IRF8_HUMAN (7-270): 1.22e-99: 301: 28.79		C2TA_HUMAN (1-1130): 0: 1043: 100.00
+	Hs
		571561 IRF2_HUMAN (1-268): 2.01e-86: 265: 45.55		C2TA_HUMAN (1-1130): 0: 1043: 100.00
+	Hs
		749477 IRF4_HUMAN (7-207): 5.81e-56: 189: 27.36		C2TA_HUMAN (1-1130): 0: 1043: 100.00
+	Mm
		663328 IRF2_MOUSE (1-259): 7.13e-83: 256: 45.22		C2TA_MOUSE (19-1130): 0: 904: 70.53
+	Mm
		1009389 IRF4_MOUSE (7-207): 4.05e-56: 190: 26.87		C2TA_MOUSE (19-1130): 0: 904: 70.53
+	Mm
		661046 IRF8_MOUSE (7-270): 2.83e-94: 287: 28.03		NLRP3_MOUSE (834-1129): 1.01e-41: 168: 15.82