HitPredict

Interactor 1: RPA1 (P10964)
DNA-directed RNA polymerase I subunit RPA190 (EC 2.7.7.6) (DNA-directed RNA polymerase I 190 kDa polypeptide) (A190) (DNA-directed RNA polymerase I largest subunit)
Gene: RPA190

Interactor 2: RPAB1 (P20434)
DNA-directed RNA polymerases I, II, and III subunit RPABC1 (RNA polymerases I, II, and III subunit ABC1) (ABC27) (DNA-directed RNA polymerases I, II, and III 27 kDa polypeptide)
Gene: RPB5

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.981

The method score is based on:

Property Details
Experiments 10393904, 11805837, 11805826, 16554755, 17179178, 21954159, 14759368, 24307683, 11918799, 16429126, 37968396, 31851481, 21048197
Identification Methods two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, affinity chromatography technology, cross-linking study
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains RNA_pol_Rpb1_1~RNA_pol_Rpb5_C, RNA_pol_Rpb1_1~RNA_pol_Rpb5_N, RNA_pol_Rpb1_5~RNA_pol_Rpb5_C, RNA_pol_Rpb1_5~RNA_pol_Rpb5_N
Common GO terms GO:0003677 - DNA binding
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005736 - RNA polymerase I complex
GO:0006360 - transcription by RNA polymerase I
and 5 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 1664
Sc

1 215
+ Hs
+ Dm
+ Bt
+ Hs
+ At
+ Sp
+ Sc
+ Hv
+ Sc
+ Hs
+ At
+ At
+ At
+ At
+ Hv

Service provided by Combinatics, Japan

Last updated: 11Aug2025