HitPredict

Interactor 1: PARP1 (P11103)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (msPARP) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (Poly [ADP-ribose] polymerase 1, 24-kDa form)]
Gene: PARP1

Interactor 2: AIRE (Q9Z0E3)
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog) (APECED protein homolog)
Gene: AIRE

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	20085707
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1013 Mm			1 552
+	Hs
		231086 PARP1_HUMAN (1-1013): 0: 1339: 91.91		AIRE_HUMAN (17-549): 2.66e-119: 364: 70.28
+	Hs
		487245 PARP1_HUMAN (1-1013): 0: 1339: 91.91		CHD3_HUMAN (32-431): 3.09e-43: 168: 15.17
+	Hs
		487242 PARP1_HUMAN (1-1013): 0: 1339: 91.91		BPTF_HUMAN (278-392): 1.34e-25: 114: 25.22
+	Hs
		487325 PARP1_HUMAN (1-1013): 0: 1339: 91.91		CHD4_HUMAN (66-540): 6.11e-24: 109: 12.50
+	Hs
		487887 PARP1_HUMAN (1-1013): 0: 1339: 91.91		TRI33_HUMAN (345-516): 8.82e-15: 79.8: 18.50
+	Hs
		355409 PARP1_HUMAN (1-1013): 0: 1339: 91.91		NSD2_HUMAN (216-391): 2.03e-12: 72.1: 21.35
+	Hs
		487640 PARP1_HUMAN (1-1013): 0: 1339: 91.91		NSD1_HUMAN (216-466): 1.92e-09: 62.9: 17.72
+	Hs
		320302 PARP1_HUMAN (1-1013): 0: 1339: 91.91		PHF14_HUMAN (128-371): 5.72e-09: 61: 14.52
+	Hs
		1088418 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		CHD3_HUMAN (32-431): 3.09e-43: 168: 15.17
+	Hs
		1041553 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		KMT2A_HUMAN (101-552): 8.16e-36: 145: 12.24
+	Hs
		1086784 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		BPTF_HUMAN (278-392): 1.34e-25: 114: 25.22
+	Hs
		1132785 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		CHD4_HUMAN (66-540): 6.11e-24: 109: 12.50
+	Hs
		1276505 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		KMT2C_HUMAN (285-552): 1.18e-23: 108: 14.59
+	Hs
		1276973 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		TRI33_HUMAN (345-516): 8.82e-15: 79.8: 18.50
+	Hs
		180862 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		TIF1A_HUMAN (407-484): 3.05e-14: 77.9: 26.92
+	Hs
		833747 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		KDM5C_HUMAN (362-485): 1.24e-13: 76.4: 12.90
+	Hs
		355548 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		NSD2_HUMAN (216-391): 2.03e-12: 72.1: 21.35
+	Hs
		892555 DNLI3_HUMAN (3-114): 1.08e-30: 132: 25.00		CHD3_HUMAN (32-431): 3.09e-43: 168: 15.17
+	Hs
		1276607 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		PF21A_HUMAN (400-485): 6.78e-12: 70.1: 18.61
+	Hs
		1276651 PARPT_HUMAN (709-1005): 1.94e-63: 229: 15.53		NSD1_HUMAN (216-466): 1.92e-09: 62.9: 17.72