Protein: AIRE
Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein)

Gene: AIRE
Organism: Homo sapiens
Interactions: 107
UniProt ID: O43918

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001673 - male germ cell nucleus
GO:0001674 - female germ cell nucleus
GO:0002458 - peripheral T cell tolerance induction
GO:0002509 - central tolerance induction to self antigen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

231072

AIRE
Autoimmune regulator

5

18

Small-scale

0.921

High

231158

CBP
CREB-binding protein

2

20

Small-scale

0.804

High

231129

H31
Histone H3.1

1

20

Small-scale

0.786

High

231132

SRSF2
Serine/arginine-rich splicing factor 2

1

14

Small-scale

0.665

High

231136

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.665

High

231148

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.647

High

231081

S10A9
Protein S100-A9

2

16

High-throughput

0.628

High

231153

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

2

1

High-throughput

0.628

High

231170

CBPA4
Carboxypeptidase A4

2

1

High-throughput

0.628

High

231091

PABP1
Polyadenylate-binding protein 1

1

12

Small-scale

0.618

High

231105

H2B1O
Histone H2B type 1-O

1

20

Small-scale

0.618

High

231112

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

20

Small-scale

0.618

High

231123

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

20

Small-scale

0.618

High

231131

SRSF3
Serine/arginine-rich splicing factor 3

1

20

Small-scale

0.618

High

231133

SRSF1
Serine/arginine-rich splicing factor 1

1

20

Small-scale

0.618

High

231135

TADBP
TAR DNA-binding protein 43

1

19

Small-scale

0.618

High

231139

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.618

High

231147

H31T
Histone H3.1t

1

20

Small-scale

0.618

High

231151

RAVR1
Ribonucleoprotein PTB-binding 1

1

17

High-throughput

0.618

High

231154

CHD6
Chromodomain-helicase-DNA-binding protein 6

1

19

Small-scale

0.618

High

231157

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.618

High

231160

H2A1C
Histone H2A type 1-C

1

20

Small-scale

0.618

High

231085

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

2

0

High-throughput

0.602

High

231096

PPAP
Prostatic acid phosphatase

2

0

High-throughput

0.602

High

231099

DDX5
Probable ATP-dependent RNA helicase DDX5

2

18

Small-scale

0.601

High

231088

BIP
Endoplasmic reticulum chaperone BiP

2

14

Small-scale

0.584

High

231173

SMC3
Structural maintenance of chromosomes protein 3

2

13

Small-scale

0.584

High

231097

H2AX
Histone H2AX

1

20

Small-scale

0.575

High

231113

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.575

High

231076

LX12B
Arachidonate 12-lipoxygenase, 12R-type

2

1

High-throughput

0.574

High

231104

TGM1
Protein-glutamine gamma-glutamyltransferase K

2

2

High-throughput

0.574

High

231169

DAXX
Death domain-associated protein 6

1

3

Small-scale

0.573

High

231090

TOP2A
DNA topoisomerase 2-alpha

1

10

Small-scale

0.536

High

231109

SPB3
Serpin B3

1

8

High-throughput

0.536

High

231111

S10A7
Protein S100-A7

1

16

High-throughput

0.536

High

231130

PRKDC
DNA-dependent protein kinase catalytic subunit

1

13

Small-scale

0.536

High

231083

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.518

High

231166

PICK1
PRKCA-binding protein

1

0

High-throughput

0.518

High

231073

RAD21
Double-strand-break repair protein rad21 homolog

1

3

Small-scale

0.515

High

231103

LMNB1
Lamin-B1

1

20

Small-scale

0.515

High

231137

ASAH1
Acid ceramidase

1

0

High-throughput

0.513

High

231107

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

7

High-throughput

0.494

High

140672

NOP56
Nucleolar protein 56

1

9

Small-scale

0.479

High

172302

XPO1
Exportin-1

1

17

Small-scale

0.479

High

220829

XPOT
Exportin-T

1

8

Small-scale

0.479

High

231075

CCNT1
Cyclin-T1

1

3

Small-scale

0.479

High

231078

IPO7
Importin-7

1

11

Small-scale

0.479

High

231079

ABL1
Tyrosine-protein kinase ABL1

1

11

High-throughput

0.479

High

231080

FYN
Tyrosine-protein kinase Fyn

1

11

High-throughput

0.479

High

231082

TBB5
Tubulin beta chain

1

11

High-throughput

0.479

High

231084

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

231086

PARP1
Poly [ADP-ribose] polymerase 1

1

20

Small-scale

0.479

High

231087

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

10

High-throughput

0.479

High

231089

HSP7C
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.479

High

231092

PCNA
Proliferating cell nuclear antigen

1

6

Small-scale

0.479

High

231093

SRC
Proto-oncogene tyrosine-protein kinase Src

1

11

High-throughput

0.479

High

231095

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

Small-scale

0.479

High

231098

NCK1
SH2/SH3 adapter protein NCK1

1

12

High-throughput

0.479

High

231101

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

1

High-throughput

0.479

High

231106

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

4

Small-scale

0.479

High

231108

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.479

High

231110

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

2

Small-scale

0.479

High

231114

MCM5
DNA replication licensing factor MCM5

1

20

Small-scale

0.479

High

231115

HS71L
Heat shock 70 kDa protein 1-like

1

11

High-throughput

0.479

High

231116

HSP74
Heat shock 70 kDa protein 4

1

16

Small-scale

0.479

High

231117

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

4

Small-scale

0.479

High

231118

MSH2
DNA mismatch repair protein Msh2

1

10

Small-scale

0.479

High

231119

CRK
Adapter molecule crk

1

8

High-throughput

0.479

High

231120

NASP
Nuclear autoantigenic sperm protein

1

7

Small-scale

0.479

High

231121

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.479

High

231122

RBP2
E3 SUMO-protein ligase RanBP2

1

8

Small-scale

0.479

High

231124

MSH6
DNA mismatch repair protein Msh6

1

13

Small-scale

0.479

High

231125

SMD3
Small nuclear ribonucleoprotein Sm D3

1

5

Small-scale

0.479

High

231127

GRB2
Growth factor receptor-bound protein 2

1

14

High-throughput

0.479

High

231128

TBB4B
Tubulin beta-4B chain

1

11

High-throughput

0.479

High

231134

SSRP1
FACT complex subunit SSRP1

1

20

Small-scale

0.479

High

231138

ATR
Serine/threonine-protein kinase ATR

1

13

Small-scale

0.479

High

231140

CUL1
Cullin-1

1

12

Small-scale

0.479

High

231141

FAT1
Protocadherin Fat 1

1

3

High-throughput

0.479

High

231142

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.479

High

231143

SMC1A
Structural maintenance of chromosomes protein 1A

1

13

Small-scale

0.479

High

231144

IMB1
Importin subunit beta-1

1

14

Small-scale

0.479

High

231145

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

Small-scale

0.479

High

231146

SF3B3
Splicing factor 3B subunit 3

1

3

Small-scale

0.479

High

231155

GEMI5
Gem-associated protein 5

1

12

Small-scale

0.479

High

231156

GCN1
Stalled ribosome sensor GCN1

1

15

Small-scale

0.479

High

231159

DDX17
Probable ATP-dependent RNA helicase DDX17

1

18

Small-scale

0.479

High

231161

RANB9
Ran-binding protein 9

1

17

Small-scale

0.479

High

231162

TBA1C
Tubulin alpha-1C chain

1

16

High-throughput

0.479

High

231163

MBB1A
Myb-binding protein 1A

1

5

Small-scale

0.479

High

231165

TMPSD
Transmembrane protease serine 13

1

3

High-throughput

0.479

High

231171

FBX3
F-box only protein 3

1

1

Small-scale

0.479

High

231172

SRRM2
Serine/arginine repetitive matrix protein 2

1

11

High-throughput

0.479

High

231174

RUVB2
RuvB-like 2

1

5

Small-scale

0.479

High

231152

NUP93
Nuclear pore complex protein Nup93

1

1

Small-scale

0.470

High

231074

4EBP3
Eukaryotic translation initiation factor 4E-binding protein 3

1

0

High-throughput

0.458

High

231126

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

231167

LANC2
LanC-like protein 2

1

0

Small-scale

0.458

High

231094

XRCC5
X-ray repair cross-complementing protein 5

1

14

Small-scale

0.445

High

231102

ATP4A
Potassium-transporting ATPase alpha chain 1

1

4

Small-scale

0.437

High

231149

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.437

High

231077

CREG1
Protein CREG1

2

0

High-throughput

0.328

High

231100

SAP3
Ganglioside GM2 activator

2

0

High-throughput

0.328

High

231150

GDPD3
Lysophospholipase D GDPD3

2

0

High-throughput

0.328

High

231164

UBAC1
Ubiquitin-associated domain-containing protein 1

1

0

Small-scale

0.251

Low

231168

CCD87
Coiled-coil domain-containing protein 87

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025