HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: MRCKB (Q9Y5S2)
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
Gene: CDC42BPB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 1711
+	Hs
		148349 ENPL_HUMAN (1-803): 0: 1073: 100.00		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		538446 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT3_HUMAN (17-411): 2.3e-122: 395: 29.75
+	Hs
		538102 ENPL_HUMAN (1-803): 0: 1073: 100.00		KAPCB_HUMAN (50-375): 2.2e-119: 382: 35.52
+	Hs
		148301 HS90B_HUMAN (75-783): 0: 997: 46.54		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		438108 HS90B_HUMAN (75-783): 0: 997: 46.54		DMPK_HUMAN (1-527): 6.24e-136: 438: 47.75
+	Hs
		148295 HS90A_HUMAN (60-783): 0: 990: 45.34		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		438633 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT3_HUMAN (17-411): 2.3e-122: 395: 29.75
+	Hs
		437907 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCL_HUMAN (70-408): 3.92e-119: 393: 34.01
+	Hs
		438637 HS90B_HUMAN (75-783): 0: 997: 46.54		ST38L_HUMAN (1-421): 5.35e-120: 388: 37.93
+	Hs
		431548 HS90A_HUMAN (60-783): 0: 990: 45.34		KPCL_HUMAN (70-408): 3.92e-119: 393: 34.01
+	Hs
		438188 HS90B_HUMAN (75-783): 0: 997: 46.54		STK38_HUMAN (4-421): 5.25e-119: 385: 38.77
+	Hs
		437870 HS90B_HUMAN (75-783): 0: 997: 46.54		KAPCA_HUMAN (48-375): 1.99e-119: 382: 34.72
+	Hs
		437900 HS90B_HUMAN (75-783): 0: 997: 46.54		KAPCB_HUMAN (50-375): 2.2e-119: 382: 35.52
+	Hs
		431511 HS90A_HUMAN (60-783): 0: 990: 45.34		KAPCA_HUMAN (48-375): 1.99e-119: 382: 34.72
+	Hs
		431538 HS90A_HUMAN (60-783): 0: 990: 45.34		KAPCB_HUMAN (50-375): 2.2e-119: 382: 35.52
+	Hs
		70435 HS90A_HUMAN (60-783): 0: 990: 45.34		B2RB89_HUMAN (50-375): 2.2e-119: 382: 35.52
+	Hs
		438190 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6A2_HUMAN (2-389): 6.73e-94: 323: 21.41
+	Hs
		438193 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		438558 HS90B_HUMAN (75-783): 0: 997: 46.54		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		438138 HS90B_HUMAN (75-783): 0: 997: 46.54		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02