Interactor 1: KRAF1 (P11346)
Raf homolog serine/threonine-protein kinase Raf (D-Raf) (dRAF-1) (EC 2.7.11.1) (Protein pole-hole)
Gene: Raf
Interactor 2: DSOR1 (Q24324)
Dual specificity mitogen-activated protein kinase kinase dSOR1 (Downstream of RAF) (MAPKK) (EC 2.7.12.2)
Gene: DSOR1
Species: Drosophila melanogaster
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.80 | 1.00 | 0.897 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 22028469, 9814705, 18494562, 16600911, unassigned4 |
| Identification Methods | affinity chromatography technology, two hybrid, protein kinase assay, experimental interaction detection |
| Interaction Type | physical association, direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~Pkinase, PK_Tyr_Ser-Thr~Pkinase |
| Common GO terms | GO:0000165 - MAPK cascade GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005829 - cytosol GO:0007173 - epidermal growth factor receptor signaling pathway and 13 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
