Protein: MP2K6
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)

Gene: MP2K6, MAP2K6
Organism: Homo sapiens
Interactions: 61
UniProt ID: P52564

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001649 - osteoblast differentiation
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

213869

M3K7
Mitogen-activated protein kinase kinase kinase 7

23

20

Small-scale

0.990

High

912506

MK14
Mitogen-activated protein kinase 14

10

20

Small-scale

0.978

High

912513

M3K5
Mitogen-activated protein kinase kinase kinase 5

9

19

Small-scale

0.969

High

858603

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

7

17

High-throughput

0.964

High

912525

M3K4
Mitogen-activated protein kinase kinase kinase 4

6

16

Small-scale

0.947

High

912508

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

20

Small-scale

0.825

High

912492

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

2

19

Small-scale

0.812

High

912493

MK12
Mitogen-activated protein kinase 12

2

20

Small-scale

0.799

High

912522

TAOK2
Serine/threonine-protein kinase TAO2

1

18

Small-scale

0.770

High

624014

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

19

Small-scale

0.724

High

912507

CDC37
Hsp90 co-chaperone Cdc37

1

11

High-throughput

0.691

High

912517

PAK6
Serine/threonine-protein kinase PAK 6

1

19

High-throughput

0.691

High

912505

PKN1
Serine/threonine-protein kinase N1

1

17

Small-scale

0.665

High

191208

TLR3
Toll-like receptor 3

1

3

Small-scale

0.647

High

374486

RASH
GTPase HRas

1

19

High-throughput

0.647

High

400518

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

High-throughput

0.647

High

578426

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.647

High

648469

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.647

High

703509

MK01
Mitogen-activated protein kinase 1

1

20

Small-scale

0.647

High

710132

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.647

High

718785

CCND2
G1/S-specific cyclin-D2

1

20

High-throughput

0.647

High

728124

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

High-throughput

0.647

High

842903

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

20

High-throughput

0.647

High

853879

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

18

Small-scale

0.647

High

879700

MAPK2
MAP kinase-activated protein kinase 2

1

14

Small-scale

0.647

High

912499

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

19

High-throughput

0.647

High

912503

STK11
Serine/threonine-protein kinase STK11

1

19

High-throughput

0.647

High

912515

GLIS2
Zinc finger protein GLIS2

1

12

High-throughput

0.647

High

912519

RASF1
Ras association domain-containing protein 1

1

20

High-throughput

0.647

High

912498

DUS4
Dual specificity protein phosphatase 4

1

8

High-throughput

0.618

High

912516

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

912518

PICK1
PRKCA-binding protein

2

5

High-throughput

0.606

High

912504

NF2L2
Nuclear factor erythroid 2-related factor 2

1

6

Small-scale

0.603

High

776943

PPM1A
Protein phosphatase 1A

1

11

Small-scale

0.575

High

912520

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

17

Small-scale

0.575

High

370173

CYTN
Cystatin-SN

1

1

High-throughput

0.536

High

874765

SPB4
Serpin B4

1

4

High-throughput

0.536

High

912497

PLCB2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

1

3

Small-scale

0.515

High

912502

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

912514

CDCA4
Cell division cycle-associated protein 4

1

0

High-throughput

0.513

High

827353

MLH1
DNA mismatch repair protein Mlh1

1

3

Small-scale

0.508

High

912500

DCTN1
Dynactin subunit 1

1

20

Small-scale

0.506

High

571188

HGF
Hepatocyte growth factor

1

5

High-throughput

0.501

High

912501

BECN1
Beclin-1

1

3

High-throughput

0.501

High

912523

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

177666

SMAD7
Mothers against decapentaplegic homolog 7

1

17

Small-scale

0.479

High

385582

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

421760

A4
Amyloid-beta precursor protein

1

10

Small-scale

0.479

High

729696

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

912494

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.479

High

912495

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

9

High-throughput

0.479

High

912496

RACK1
Small ribosomal subunit protein RACK1

1

15

Small-scale

0.479

High

912509

FBX31
F-box only protein 31

1

1

Small-scale

0.479

High

912511

CARM1
Histone-arginine methyltransferase CARM1

1

5

High-throughput

0.479

High

912521

XPO7
Exportin-7

1

14

High-throughput

0.479

High

912524

TRAF6
TNF receptor-associated factor 6

1

16

Small-scale

0.479

High

301373

WFS1
Wolframin

1

1

High-throughput

0.470

High

912512

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.458

High

912510

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.445

High

388613

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025