HitPredict

Interactor 1: ATF2 (P15336)
Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1)
Gene: ATF2

Interactor 2: Q6FG41 (Q6FG41)
Protein c-Fos (Cellular oncogene fos)
Gene: FOS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	bZIP_1~bZIP_1
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 505 Hs			1 380
+	Hs
		345305 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		FOS_HUMAN (1-380): 1.68e-84: 263: 100.00
+	Hs
		345313 ATF7_HUMAN (19-500): 5.33e-94: 295: 54.29		FOS_HUMAN (1-380): 1.68e-84: 263: 100.00
+	Hs
		547848 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		BACH2_HUMAN (14-307): 4.1e-34: 136: 13.65
+	Hs
		547676 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		FOSL1_HUMAN (59-287): 1.43e-34: 130: 37.61
+	Hs
		157172 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		BACH1_HUMAN (4-295): 1.68e-30: 125: 12.99
+	Hs
		547688 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		ATF7_HUMAN (82-289): 7.9e-31: 124: 16.59
+	Hs
		547677 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		FOSL2_HUMAN (2-380): 3.19e-31: 122: 39.54
+	Hs
		547675 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57
+	Hs
		547755 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		FOSB_HUMAN (2-380): 1.59e-25: 107: 34.24
+	Hs
		547788 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		CREB5_HUMAN (92-233): 1.13e-24: 107: 19.01
+	Hs
		547856 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		BATF3_HUMAN (120-228): 1.45e-27: 107: 27.52
+	Hs
		547685 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		JUNB_HUMAN (85-215): 3.19e-25: 106: 19.86
+	Hs
		401356 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		JUN_HUMAN (48-215): 1.19e-23: 102: 16.47
+	Hs
		547696 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		ATF3_HUMAN (131-215): 4.23e-25: 102: 43.53
+	Hs
		547810 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		BATF_HUMAN (132-233): 4.1e-25: 100: 30.39
+	Hs
		547831 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		JDP2_HUMAN (147-220): 1.47e-21: 92: 37.84
+	Mm
		562970 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62
+	Hs
		547687 ATF2_HUMAN (1-495): 3.36e-131: 392: 100.00		JUND_HUMAN (112-215): 1.79e-13: 72.8: 20.00
+	Mm
		562976 ATF2_MOUSE (19-505): 3.6e-115: 350: 99.18		JDP2_MOUSE (147-220): 4.05e-21: 90.9: 37.84
+	Hs
		157176 ATF7_HUMAN (19-500): 5.33e-94: 295: 54.29		BACH1_HUMAN (4-295): 1.68e-30: 125: 12.99