Interactor 1: ODBA (P12694)
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)
Gene: BCKDHA
Interactor 2: ODBB (P21953)
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)
Gene: BCKDHB
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.90 | 1.00 | 0.953 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28514442, 33961781, 10745006, 12902323, 15166214, 15576032 |
| Identification Methods | affinity chromatography technology, pull down, molecular sieving, x-ray crystallography, anti tag coimmunoprecipitation |
| Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | E1_dh~Transket_pyr, E1_dh~Transketolase_C |
| Common GO terms | GO:0003863 - branched-chain 2-oxo acid dehydrogenase activity GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0009083 - branched-chain amino acid catabolic process GO:0160157 - branched-chain alpha-ketoacid dehydrogenase complex |
| Homologous interactions | 17 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
