Protein: ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (EC 1.2.4.1) (Pyruvate dehydrogenase complex component E1 beta) (PDHE1-B)

Gene: ODPB, PDB1
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P32473

Gene Ontology (top 5):
GO:0004739 - pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005739 - mitochondrion
GO:0006086 - pyruvate decarboxylation to acetyl-CoA
GO:0042645 - mitochondrial nucleoid
GO:0045254 - pyruvate dehydrogenase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554894

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

6

8

High-throughput

0.943

High

594912

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

4

16

High-throughput

0.892

High

484740

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

4

4

High-throughput

0.691

High

596803

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

4

9

High-throughput

0.691

High

737442

PREP
Presequence protease, mitochondrial

3

3

High-throughput

0.662

High

737452

TCM62
Mitochondrial chaperone TCM62

3

3

High-throughput

0.643

High

737439

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

2

2

High-throughput

0.621

High

635944

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

11

High-throughput

0.618

High

678778

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

2

2

High-throughput

0.611

High

737437

DUR1
Urea amidolyase [Includes: Urea carboxylase

2

0

High-throughput

0.595

High

737468

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.588

High

726842

HS104
Heat shock protein 104

3

3

Small-scale

0.585

High

510305

HSP77
Import motor subunit, mitochondrial

2

4

High-throughput

0.584

High

737443

HSP78
Heat shock protein 78, mitochondrial

2

3

High-throughput

0.584

High

626653

HSP60
Heat shock protein 60, mitochondrial

2

2

High-throughput

0.571

High

737479

RM22
Large ribosomal subunit protein uL22m

2

1

High-throughput

0.571

High

734634

IMB3
Importin subunit beta-3

2

1

High-throughput

0.567

High

737507

PRP46
Pre-mRNA-splicing factor PRP46

2

4

High-throughput

0.567

High

737511

CMR1
DNA damage-binding protein CMR1

2

5

High-throughput

0.533

High

737470

AIM23
Altered inheritance of mitochondria protein 23, mitochondrial

1

0

High-throughput

0.493

High

364977

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.489

High

579039

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

594253

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

604926

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

619337

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

8

High-throughput

0.479

High

622337

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

642130

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

685099

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

721681

RF1M
Peptide chain release factor 1, mitochondrial

1

3

High-throughput

0.479

High

737466

ETFB
Probable electron transfer flavoprotein subunit beta

1

1

High-throughput

0.479

High

737476

ALAT1
Alanine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

737480

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

737481

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.479

High

737491

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.479

High

737512

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

737500

CDC73
Cell division control protein 73

1

1

High-throughput

0.470

High

737501

ADY3
Accumulates dyads protein 3

1

1

High-throughput

0.470

High

704579

SBA1
Co-chaperone protein SBA1

1

1

High-throughput

0.464

High

401929

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

439108

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

452644

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

647960

RM20
Large ribosomal subunit protein mL58

1

0

High-throughput

0.458

High

694465

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

0

High-throughput

0.458

High

725691

RM09
Large ribosomal subunit protein uL3m

1

0

High-throughput

0.458

High

737440

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.458

High

737441

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

737447

RM38
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.458

High

737450

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

737454

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

737455

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

737458

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

737460

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

0

High-throughput

0.458

High

737465

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

737474

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

737475

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

737486

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

737487

ESP1
Separin

1

0

High-throughput

0.458

High

737492

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

737495

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

737509

RM23
Large ribosomal subunit protein uL13m

1

0

High-throughput

0.458

High

509451

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.457

High

517952

SSBP1
Single-stranded nucleic acid-binding protein

1

1

High-throughput

0.457

High

453480

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

526177

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

381949

H4
Histone H4

1

1

High-throughput

0.437

High

392416

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.437

High

558639

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

661478

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.437

High

670467

SIS1
Protein SIS1

1

4

High-throughput

0.437

High

706502

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

734593

NUD1
Protein NUD1

1

1

High-throughput

0.437

High

737449

CENPA
Histone H3-like centromeric protein CSE4

1

2

High-throughput

0.437

High

737451

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

737453

GID4
GID complex substrate-recognition subunit 4

1

1

High-throughput

0.437

High

737457

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.437

High

737459

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

737463

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

737467

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.437

High

737482

H3
Histone H3

1

2

High-throughput

0.437

High

737488

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.437

High

737489

ESC1
Silent chromatin protein ESC1

1

1

High-throughput

0.437

High

737490

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

737497

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

737503

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

737505

ARP8
Actin-like protein ARP8

1

1

High-throughput

0.437

High

737506

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.437

High

737508

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.437

High

394349

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

737478

PBP1
PAB1-binding protein 1

1

0

High-throughput

0.426

High

523363

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.407

High

544168

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.407

High

592095

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

734042

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

737438

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.407

High

737461

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.407

High

737499

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.407

High

737483

AP1M1
AP-1 complex subunit mu-1-I

2

0

High-throughput

0.307

High

737484

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.307

High

737493

NTE1
Lysophospholipase NTE1

2

0

High-throughput

0.307

High

737496

YL345
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase

1

0

High-throughput

0.265

Low

268871

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

427181

RLA0
Large ribosomal subunit protein uL10

1

0

Small-scale

0.249

Low

441776

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

502915

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

504100

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

513835

RS11B
Small ribosomal subunit protein uS17B

1

0

High-throughput

0.249

Low

676615

SGF29
SAGA complex subunit SGF29

1

0

Small-scale

0.249

Low

737444

IF4B
Eukaryotic translation initiation factor 4B

1

0

High-throughput

0.249

Low

737445

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

737446

SPT21
Protein SPT21

1

0

High-throughput

0.249

Low

737448

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

737456

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

737462

ULP2
Ubiquitin-like-specific protease 2

1

0

Small-scale

0.249

Low

737464

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

737471

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

737472

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

737473

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

737477

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

737485

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

737494

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.249

Low

737498

SEC10
Exocyst complex component SEC10

1

0

Small-scale

0.249

Low

737469

RSSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low

737502

AB140
tRNA(Thr)

1

0

High-throughput

0.232

Low

737504

MAM3
Protein MAM3

1

0

High-throughput

0.232

Low

737510

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025