HitPredict

Interactor 1: FGFR1 (P16092)
Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FRS3 (Q91WJ0)
Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta)
Gene: FRS3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17901128, 16887332
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Mm			1 492
+	Hs
		207292 FGFR1_HUMAN (1-822): 0: 847: 98.42		FRS3_HUMAN (1-492): 0: 647: 85.08
+	Hs
		508122 FGFR1_HUMAN (1-822): 0: 847: 98.42		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Mm
		555269 FGFR1_MOUSE (1-822): 0: 849: 100.00		FRS2_MOUSE (1-492): 0: 571: 46.07
+	Hs
		601554 FGFR2_HUMAN (1-812): 0: 787: 71.26		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		609443 FGFR3_HUMAN (1-808): 0: 721: 61.93		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		608060 FGFR4_HUMAN (30-807): 0: 649: 56.39		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		872680 EPHA4_HUMAN (3-821): 0: 634: 18.53		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		1081545 NTRK3_HUMAN (111-762): 9.47e-171: 516: 23.30		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		1083873 NTRK2_HUMAN (58-762): 4.26e-161: 490: 22.52		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		385225 NTRK1_HUMAN (122-762): 2.06e-154: 472: 26.10		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Hs
		434249 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		FRS2_HUMAN (1-492): 0: 584: 45.87
+	Mm
		1101896 NTRK3_MOUSE (111-762): 6.07e-175: 526: 24.08		DOK6_MOUSE (34-184): 1.04e-28: 117: 26.83
+	Hs
		1081513 NTRK3_HUMAN (111-762): 9.47e-171: 516: 23.30		DOK6_HUMAN (34-151): 2.04e-28: 116: 27.05
+	Hs
		434273 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK1_HUMAN (19-313): 3.72e-51: 182: 20.88
+	Hs
		235038 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK2_HUMAN (20-290): 5.37e-32: 128: 21.31
+	Hs
		434219 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK6_HUMAN (34-151): 2.04e-28: 116: 27.05
+	Hs
		434248 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK4_HUMAN (34-143): 1.99e-27: 114: 21.93
+	Hs
		434299 RET_HUMAN (228-820): 4.18e-132: 423: 35.34		DOK5_HUMAN (34-139): 4.42e-27: 112: 24.58
+	Mm
		452182 CSF1R_MOUSE (464-769): 9.31e-78: 273: 42.11		DOK1_MOUSE (19-247): 1.51e-61: 210: 24.90
+	Hs
		235075 TIE2_HUMAN (484-771): 4.49e-69: 249: 45.52		DOK2_HUMAN (20-290): 5.37e-32: 128: 21.31